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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authorative database
Reference:
Composition 1
Qualifier:
according to
Guideline:
other: Refer below principle
Principles of method if other than guideline:
Environmental Bioconcentration of test substance oil pink was determine in aquatic organisms using a measured log Kow of 7.5 and a recommended regression-derived equation
GLP compliance:
not specified
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material: 1-[(2-methoxyphenyl)azo]-2-naphthol
- Molecular formula: C17 H14 N2 O2
- Molecular weight: 278.31 g/mol
- Smiles notation: c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type: Organic
- Physical state: solid
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
not specified
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
TOC:
No data
Salinity:
No data
Conductivity:
No data
Details on test conditions:
No data
Nominal and measured concentrations:
No data
Reference substance (positive control):
not specified
Key result
Type:
BCF
Value:
290 000 dimensionless
Basis:
whole body w.w.
Remarks on result:
other: BCF value indicates that bioconcentration in aquatic organisms will be an important fate process
Validity criteria fulfilled:
not specified
Conclusions:
From authorative database HSDB The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation.
Executive summary:

From authorative database HSDB The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation.This BCF value indicates that bioconcentration in aquatic organisms will be an important fate process.

Description of key information

From authorative database HSDB The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation. This BCF value indicates that bioconcentration in aquatic organisms will be an important fate process i.e chemical have concern for bioaccumulation in aquatic environment.

Key value for chemical safety assessment

BCF (aquatic species):
290 000 dimensionless

Additional information

Two results including predicted data from authorative database and validated models for bioaccumulation (BCF) endpoint of target chemical 1-[(2-methoxyphenyl)azo]-2-naphthol (Cas no. 1229-55-6) were summarized as follows:

 

First study from authorative database HSDB; 2017 suggest The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation. This BCF value indicates that bioconcentration in aquatic organisms will be an important fate process i.e chemical have concern for bioaccumulation in aquatic environment.

Above result assist by prediction done using Bio-concentration Factor (v12.1.0.50374) module from ACD (Advanced Chemistry Development)/I-Lab to determine Bio-concentration Factor over the entire pH scale 1-14 of the test substance 1-[(2-methoxyphenyl)azo]-2-naphthol.BCF  estimated to be in the range 1066 to 3662 (dimentionless). This value indicates that the test substance 1-[(2-methoxyphenyl)azo]-2-naphthol was likely to be Bioaccumulative in aquatic organisms. 

Thus based on the above information for bioaccumulation endpoint, it can be concluded that the test substance 1-[(2-methoxyphenyl)azo]-2-naphthol (Cas no. 1229-55-6)is expected to be Bioaccumulative in aquatic environment as both studies indicate the chemical 1-[(2-methoxyphenyl)azo]-2-naphthol exceed the BCF threshold of 2000.