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EC number: 214-968-9 | CAS number: 1229-55-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authorative database
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Environmental Bioconcentration of test substance oil pink was determine in aquatic organisms using a measured log Kow of 7.5 and a recommended regression-derived equation
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 1-[(2-methoxyphenyl)azo]-2-naphthol
- Molecular formula: C17 H14 N2 O2
- Molecular weight: 278.31 g/mol
- Smiles notation: c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type: Organic
- Physical state: solid - Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- not specified
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- TOC:
- No data
- Salinity:
- No data
- Conductivity:
- No data
- Details on test conditions:
- No data
- Nominal and measured concentrations:
- No data
- Reference substance (positive control):
- not specified
- Key result
- Type:
- BCF
- Value:
- 290 000 dimensionless
- Basis:
- whole body w.w.
- Remarks on result:
- other: BCF value indicates that bioconcentration in aquatic organisms will be an important fate process
- Validity criteria fulfilled:
- not specified
- Conclusions:
- From authorative database HSDB The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation.
- Executive summary:
From authorative database HSDB The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation.This BCF value indicates that bioconcentration in aquatic organisms will be an important fate process.
Reference
Description of key information
From authorative database HSDB The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation. This BCF value indicates that bioconcentration in aquatic organisms will be an important fate process i.e chemical have concern for bioaccumulation in aquatic environment.
Key value for chemical safety assessment
- BCF (aquatic species):
- 290 000 dimensionless
Additional information
Two results including predicted data from authorative database and validated models for bioaccumulation (BCF) endpoint of target chemical 1-[(2-methoxyphenyl)azo]-2-naphthol (Cas no. 1229-55-6) were summarized as follows:
First study from authorative database HSDB; 2017 suggest The BCF of oil pink i.e 1-[(2-methoxyphenyl)azo]-2-naphthol in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation. This BCF value indicates that bioconcentration in aquatic organisms will be an important fate process i.e chemical have concern for bioaccumulation in aquatic environment.
Above result assist by prediction done using Bio-concentration Factor (v12.1.0.50374) module from ACD (Advanced Chemistry Development)/I-Lab to determine Bio-concentration Factor over the entire pH scale 1-14 of the test substance 1-[(2-methoxyphenyl)azo]-2-naphthol.BCF estimated to be in the range 1066 to 3662 (dimentionless). This value indicates that the test substance 1-[(2-methoxyphenyl)azo]-2-naphthol was likely to be Bioaccumulative in aquatic organisms.
Thus based on the above information for bioaccumulation endpoint, it can be concluded that the test substance 1-[(2-methoxyphenyl)azo]-2-naphthol (Cas no. 1229-55-6)is expected to be Bioaccumulative in aquatic environment as both studies indicate the chemical 1-[(2-methoxyphenyl)azo]-2-naphthol exceed the BCF threshold of 2000.
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