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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviwed journals
Reference:
Composition 1
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Principles of method if other than guideline:
To determine the octanol water partition coefficient of Solvent Red 1 by HPLC method
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material: 1-[(2-methoxyphenyl)diazenyl]-2-naphthol
- Common Name: Solvent Red 1
- Molecular formula: C17H14N2O2
- Molecular weight: 278.31 g/mol
- Smiles notation: c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type: Organic
- Physical state: Solid
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
7.5
Remarks on result:
other: no other details mentioned
Conclusions:
The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5
Executive summary:

Capacity factors were determined for 20 disperse and solvent dyes by a high performance liquid chromatographic method using methanol/water and a C-18 reverse-phase column. Regression equations are given that establish relationships among capacity factors, water solubilities and octanol/water partition coefficients. The method used was similar to OECD GUIDELINES 117.

The liquid chromatographic system comprised a PerkinElmer Series 2000 pump, a Varian Vari-Chrom absorbance detector and an Alltech Econosil C-18 (10.urn)column (4,6 mm x 25 cm with guard column). The mobile phase, HPLC-grade methanol and deionized water (75/25 vol. %), was filtered for use at a flow rate of 1,3 ml/min, Detection was at the wavelength of maximum absorbance in the visible spectra.

The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5

Description of key information

Capacity factors were determined for 20 disperse and solvent dyes by a high performance liquid chromatographic method using methanol/water and a C-18 reverse-phase column. Regression equations are given that establish relationships among capacity factors, water solubilities and octanol/water partition coefficients. The method used was similar to OECD GUIDELINES 117.

The liquid chromatographic system comprised a PerkinElmer Series 2000 pump, a Varian Vari-Chrom absorbance detector and an Alltech Econosil C-18 (10.urn)column (4,6 mm x 25 cm with guard column). The mobile phase, HPLC-grade methanol and deionized water (75/25 vol. %), was filtered for use at a flow rate of 1,3 ml/min, Detection was at the wavelength of maximum absorbance in the visible spectra.

The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5

Key value for chemical safety assessment

Log Kow (Log Pow):
7.5

Additional information

Capacity factors were determined for 20 disperse and solvent dyes by a high performance liquid chromatographic method using methanol/water and a C-18 reverse-phase column. Regression equations are given that establish relationships among capacity factors, water solubilities and octanol/water partition coefficients. The method used was similar to OECD GUIDELINES 117.

The liquid chromatographic system comprised a PerkinElmer Series 2000 pump, a Varian Vari-Chrom absorbance detector and an Alltech Econosil C-18 (10.urn)column (4,6 mm x 25 cm with guard column). The mobile phase, HPLC-grade methanol and deionized water (75/25 vol. %), was filtered for use at a flow rate of 1,3 ml/min, Detection was at the wavelength of maximum absorbance in the visible spectra.

The experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was determined to be 7.5

Data from various authoritative databases and peer reviewed articles also indicate that the experimental octanol water partition coefficient (log Pow) of Solvent Red 1 was 7.5