Registration Dossier
Registration Dossier
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EC number: 201-757-1 | CAS number: 87-61-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Title:
- No information
- Author:
- Zub M (1978). Reactivity of the white blood cell system to toxic action benzene and its derivatives. Acta Biol. 21, 163-174
Materials and methods
- Principles of method if other than guideline:
- Method: other: 5 mice/sex, whole-body exposure
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: Trichlorobenzene isomere not specified, no data on purity
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 3 weeks, 3 months
- Frequency of treatment:
- daily, 7 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 weeks: 500 mg/m³, 3 months: 20 mg/m³
Basis
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
3-weeks exposure:
all animals survived, hypoactivity, lack of appetite, matted hair
Leukopenia, lymphocytosis in the peripheral blood, fatty degeneration in the liver
3 months exposure:
body weight loss, matted hair, drowsiness,
Leukopenia, lymphocytosis, neutropenia, degenerative changes in the thymus,intense desintegration of lymphocytes
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
