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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
29/01/2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Reference:
Composition 0
Principles of method if other than guideline:
BCF estimation is performed by the BCF base-line model v.02.05. The model evaluates the maximum bioconcentration potential (log BCFmax) of chemicals based on their lipophilicity and further applies mitigating factors that can reduce the calculated maximum value.
GLP compliance:
no
Test material information:
Composition 1
Key result
Value:
32 dimensionless
Calculation basis:
other: QSAR model
Remarks on result:
not measured/tested
Conclusions:
Component A F-2200
Component A is characterized by high lipophilicity. Although its log Kow value (log Kow=5.74) would classify it as bioaccumulative, mitigating factors are taken into consideration which reduced its maximum bioaccumulation potential. The BCF base-line model estimates that size and metabolism as most significant mitigating factors reducing its bioaccumulation down to log BCF = 1.51 leading to ultimate classification as Not bioaccumulative.
The results are confirmed by observed data for structural analogues identified in the Toolbox (also in training set of the BCF base-line model).

Executive summary:

Component A  F-2200

Component A is characterized by high lipophilicity.  Although its log Kow value (log Kow=5.74) would classify it as bioaccumulative, mitigating factors are taken into consideration which reduced its maximum bioaccumulation potential.  The BCF base-line model estimates that size and metabolism as most significant mitigating factors reducing its bioaccumulation down to log BCF = 1.51  leading to ultimate classification as Not bioaccumulative.

The results are confirmed by observed data for structural analogues identified in the Toolbox (also in training set of the BCF base-line model).

Description of key information

Component A  F-2200

Component A is characterized by high lipophilicity.  Although its log Kow value (log Kow=5.74) would classify it as bioaccumulative, mitigating factors are taken into consideration which reduced its maximum bioaccumulation potential.  The BCF base-line model estimates that size and metabolism as most significant mitigating factors reducing its bioaccumulation down to log BCF = 1.51  leading to ultimate classification as Not bioaccumulative.

The results are confirmed by observed data for structural analogues identified in the Toolbox (also in training set of the BCF base-line model).

Key value for chemical safety assessment

BCF (aquatic species):
32 dimensionless

Additional information