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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Internationally accepted calculation method, EPI-Suite EPA (USA).
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
Calculation by EPI-Suite BIOWIN v4.10.
GLP compliance:
no
Specific details on test material used for the study:
SMILES : CN(C)C3CC(C)OC(OC2C(C)C(OC1CC(C)(OC)C(O)C(C)O1)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=NO)C(C)CC2(C)OC)C3O
Details on study design:
Estimated by calculation
Key result
Parameter:
not specified
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction

Probability of Rapid Biodegradation (BIOWIN v4.10):

Biowin1 (Linear Model)        : -1.8065

Biowin2 (Non-Linear Model)    :  0.0000

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model):  1.1900 (recalcitrant)

Biowin4 (Primary Survey Model) :  2.5575 (weeks-months)

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model)   : -0.3027

Biowin6 (MITI Non-Linear Model):  0.0000

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): -3.0711

Ready Biodegradability Prediction:  NO

Validity criteria fulfilled:
not applicable
Interpretation of results:
not readily biodegradable
Conclusions:
The substance is predicted not to be readily biodegradable by EPI-Suite BIOWIN v4.10.
Executive summary:

The substance is predicted not to be readily biodegradable by EPI-Suite BIOWIN v4.10.

Description of key information

Key study: Internationally accepted calculation method, EPI-Suite EPA (USA). The substance is predicted not to be readily biodegradable by EPI-Suite BIOWIN v4.10.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information