2-chlorophenol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given

Remarks:

(no details on study design and results provided)

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

- Principle of test: 4 New Zealand white rabbits were exposed to the test item for 24 h. Applied doses were 631, 1000 and 1580 mg/kg bw, group sizes were n=1, n=1 and n=2, respectively. The observation period was 14 days.
- Parameters analysed / observed: mortality, clinical signs, gross autopsy

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-chlorophenol

EC Number:

202-433-2

EC Name:

2-chlorophenol

Cas Number:

95-57-8

Molecular formula:

C6H5ClO

IUPAC Name:

2-chlorophenol

Test material form:

liquid

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
-Lot/batch No.of test material: KL 1003

Test animals

Species:

rat

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 h

Doses:

631, 1000, 1580 mg/kg bw

No. of animals per sex per dose:

631 mg/kg bw: 1 female
1000 mg/kg bw: 1 male
1580 mg/kg bw: 1 male and 1 female

Control animals:

not required

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross autopsy

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 000 - < 1 580 mg/kg bw

Based on:

test mat.

Mortality:

Mortality was observed after topical application of 1580 mg/kg bw in 2/2 test animals within 2 days. No mortalities were noted at the mid and low dose.

Clinical signs:

Reduced appetite and activity (three to five days in survivors), increasing weakness, collapse and death were observed.

Gross pathology:

In decedents, lung and liver hyperemia, enlarged gall bladder, darkened kidney and spleen, and gastrointestinal inflammation were observed.
In survivors, viscera appeared normal after the end of the observation period of 14 days.

Any other information on results incl. tables

Dose [mg/kg bw]	Toxicological results*	Mortality (%)
Males
631	0/0	---
1000	0/1	0
1580	1/1	100
Females
631	0/1	0
1000	0/0	---
1580	1/1	100
LD50 >1000 < 1580 mg/kg
* first number = number of dead animals
second number = number of animals used

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

CLP: Acute toxicity, Cat. 4, H312