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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
REPORTS of the Scientific Committee on Cosmetology (seventh series)
Author:
Published by the COMMISSION OF THE EUROPEAN COMMUNITIES; Directorate-General Telecommunications, Information Industries and Innovation
Year:
1988
Bibliographic source:
Scientific Committee on Cosmetology (seventh series), 1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Eye irritation studies were carried out to test the toxicity of the test chemical in rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
EC Number:
201-635-8
EC Name:
1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
Cas Number:
85-83-6
Molecular formula:
C24H20N4O
IUPAC Name:
1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
- Common name: Scarlet red, Sudan IV
- Molecular formula: C24H20N4O
- Molecular weight: 380.449 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
not specified

Test system

Vehicle:
other: 8 drops of Propanediol
Controls:
not specified
Amount / concentration applied:
100mg in 8 drops of Propanediol
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritant / corrosive response data:
slightly irritating to eyes

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Remarks:
EU
Conclusions:
The test chemical was determined to be slightly irritating to rabbit eyes.
Executive summary:

In an eye irritation test in rabbits, 100 mg of the test chemical was made into a paste with 8 drops of 1,2-propanediol and instilled into the rabbits eyes

The rabbits were observed (duration not specified) for ocular reactions to the test chemical.

The test chemical was considered to be slightly irritating to the mucous membranes.