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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognised method, with some non-critical deviations. The substance is considered to be adequately characterised with its purity. Therefore validation applies with restrictions.
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
loading rate
Principles of method if other than guideline:
Not applicable
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
709 mg/L
Conc. based on:
test mat. (dissolved fraction)
Loading of aqueous phase:
20 g/L
Incubation duration:
24 - 72 h
Temp.:
20 °C
pH:
5

 mg/L  24 h  48 h  72 h  pH
 flask 1

796

787

781

mean 788

770

769

768

mean 769 

791

733

728

mean 750 

 5.0
 flask 2

778

773

773

mean 774

622

621

623

mean 622 

645

638

639

mean 641 

 5.0
 flask 3

718

730

725

mean 724 

590

588

588

mean 589 

723

725

730

mean 726 

 5.0
 average +/-SD (%RSD)

762 

+/- 34 (4.4%)

660 

+/- 96 (14.5%)

706 

+/- 58 (8.2%)

 
  709  

No increasing tendency was observed, and results are within the acceptable variability limit of 15% (-13% between 24 and 48h), therefore the mean of all results was retained.

Conclusions:
Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
Executive summary:

The water solubility of the test substance was measured according to EU method A6, flask method, with some non-critical deviations. Three flasks, with a loading rate of 20 g/L were presaturated at 30°C, and equilibrated for at 20°C. Each flask was sampled at 24, 48 and 72h, and each sample analysed in triplicate with HPLC. Results show variability, but in the acceptable range, so the mean value was retained.

The water solubility of the test substance was determined to be 709 mg/L (pH 5).

Description of key information

Considered as moderately soluble, with equilibrium reached from =< 24h. pH of saturated solution: 5.0.

Key value for chemical safety assessment

Water solubility:
709 mg/L
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted similarly to OECD method, is available. Despite restrictions (deviations leading to inaccuracy) it is considered as a key study. The result is retained as key data.