Registration Dossier
Registration Dossier
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EC number: 606-278-5 | CAS number: 19257-34-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Remarks on result:
- not determinable
- Remarks:
- hydrolytical instability of the test substance in water
- Conclusions:
- Decomposes. The solubility of the substance in distilled water cannot be determined due to hydrolytic instability of the test substance.
- Executive summary:
The water solubility was determined according to the OECD guideline 105 and EU method A.6 using the flaks method.
The solubility of the substance in distilled water cannot be determined due to hydrolytic instability of the test substance. Suspensions of the test item in distilled water show a pH value of approx. 4. Due to fast hydrolytic degradation at this pH value, the solubility equilibrium could not be reached. Samples taken after different time intervals, until a total time of approx. 24 hours, show results similar to those already measured in aqueous solutions buffered to pH 7 and 9 (solubilities at 20 °C: 0.027 g/L at pH 7, 0.031 g/L at pH 9, see Schering report APC 21/00). This is also to be expected since the substance does not show functional groups that can be protonated or deprotonated.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- buffered to pH 7 and 9
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- buffered to pH 7 and 9
- Principles of method if other than guideline:
- As part of a program to determine the physical and chemical characteristics of the substance, the water solubility was determined at 20 °C following OECD guideline no. 105 and EC testing guideline no. A.6 using the flask method.
Due to the hydrolytic instability of the substance at acidic pH values the solubility could not be determined in distilled water or at pH values below 7. The solubility was therefore measured in aqueous solutions buffered to pH values of 7 and 9 using the flask method. - GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.027 g/L
- Temp.:
- 20 °C
- pH:
- 7.04
- Remarks on result:
- other: 95 % confidence intervals: 0.026 - 0.029 g/L
- Water solubility:
- 0.031 g/L
- Temp.:
- 20 °C
- pH:
- 8.97
- Remarks on result:
- other: 95 % confidence intervals: 0.030 - 0.033 g/L
- Details on results:
- No change of the solid state form was observed during the solubility experiment since the X-ray powder diffractograms of the insoluble residues after t = 3 days and of the starting material were identical.
- Conclusions:
- Slightly soluble (0.1-100 mg/L).
The solubility of the substance at 20 °C was determined in aqueous solutions buffered to pH 7 and 9 using the flask method. The measurement showed a solubility to pH 7 at 0.027 g/L and to pH 9 at 0.031 g/L. Buffer solutions were used due to hydrolytic instability at acidic pH values. - Executive summary:
The solubility of the substance was determined according to OECD guideline 105 and EU Method A.6 using the flask method.
Due to the hydrolytic instability of the substance at acidic pH values the solubility could not be determined in distilled water or at pH values below 7. The solubility was therefore measured in aqueous solutions buffered to pH values of 7 and 9 using the flask method.
The measurement showed a solubility to pH 7 at 0.027 g/L and to pH 9 at 0.031 g/L.
No change of the solid state form was observed during the solubility experiment since the X-ray powder diffractograms of the insoluble residues after t = 3 days and of the starting material were identical.
Referenceopen allclose all
The solubility of the substance in distilled water cannot be determined due to hydrolytic instability of the test substance. Suspensions of the test item in distilled water show a pH value of approx. 4. Due to fast hydrolytic degradation at this pH value, the solubility equilibrium could not be reached. Samples taken after different time intervals, until a total time of approx. 24 hours, show results similar to those already measured in aqueous solutions buffered to pH 7 and 9 (solubilities at 20 °C: 0.027 g/L at pH 7, 0.031 g/L at pH 9, see Schering report APC 21/00). This is also to be expected since the substance does not show functional groups that can be protonated or deprotonated.
Description of key information
Water solubility: The solubility of the substance in distilled water cannot be determined due to hydrolytic instability of the test substance.
Buffered aqueous solution: The solubility of the substance at 20 °C was determined in aqueous solutions buffered to pH 7 and 9 using the flask method. The measurement showed a solubility at pH 7 of 0.027 g/L and at pH 9 of 0.031 g/L.
Key value for chemical safety assessment
- Water solubility:
- 0.027 g/L
- at the temperature of:
- 20 °C
Additional information
The solubility of the substance was measured in aqueous solutions buffered to pH 7.
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