Registration Dossier
Registration Dossier
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EC number: 606-278-5 | CAS number: 19257-34-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.04
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: 95% confidence limits: 3.85 - 4.23
- Conclusions:
- The partition coefficient of the substance was determined as log Pow = 4.04 at 25 °C and pH7.
- Executive summary:
The n-octanol/water partition coefficient of the substance was determined according to EU Testing Guideline A.8 (HPLC method based on OECD guideline no. 117) to be log Pow = 4.04 (95 % confidence limits 3.85 - 4.23). This method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.
Reference
The log Pow value of the test compound was calculated from its log k' and the calibration line to be (at 25 °C):
| compound | retention times [min] | log k' |
log Pow |
|||
| 1. | 2. | 3. | Ø | with 95 % confidence limits | ||
| Test item | 5.79 | 5.79 | 5.79 | 5.79 | 0.71 | 4.04 (3.85 - 4.23) |
The evaluations were made with the program Pow 1.2 (PDR Informatik, Schering AG).
Description of key information
The partition coefficient (logPow) of 4.0 was determined at 25 °C and pH7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.04
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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