N-methylformanilide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20-07-2017 – 24-07-2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

The water solubility determination of test item N-Methylformanilide (CAS No. 93-61-8) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101.

GLP compliance:

no

Type of method:

other: spectrophotometric analytical method

Specific details on test material used for the study:

- Name of test material (as cited in study report): N-methylformanilide
- Molecular formula: C8 H9 N O
- Molecular weight : 135.165g/mol
- Smiles notation: O=CN(c1ccccc1)C
- InChl: 1S/C8H9NO/c1-9(7-10)8-5-3-2-4-6-8/h2-7H,1H3
- Substance type: Organic
- Physical state: Liquid

Key result

Water solubility:

4 326 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

Remarks on result:

other: other details not specified

WATER SOLUBILITY: CONFIRMATORY TEST

Five times the concentration recorded from preliminary solubility = 1084.8 mg/L × 5 = 5424 mg/L was used for confirmatory

study. Two separate solution of 542.4 mg in 100 ml DI water were prepared and kept for stirring for 48 hrs and 72 hrs. After

the completion of stirring period the absorbance for all the two solution were recorded and concentration was detected on the

basis of standard curve. Table 2 refers to the same.

Confirmatory test: Not applicable
Table 2:

Sample stirring	Concentration obtained on the basis of standard curve	Dilution factor	Solubility value obtained (mg/L)
24 hour	-	-	-
48 hour	9.899 mg/L	400	3959.6 mg/L
72 hour	11.731 mg/L	400	4692.4 mg/L

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

= (3959.6+4692.4)/2

= 4326 mg/L

Conclusions:

The water solubility for the test item N-Methylformanilide was determined to be 4326 mg/L at 25°C.

Executive summary:

The water solubility determination of test item N-Methylformanilide (CAS No. 93-61-8) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of (N-Methylformanilide of 93-61-8) in water was determined to be 4326 mg/L at 25°C.

Thus based on obtained value the given chemical N-Methylformanilide is considered to be soluble in water.

Description of key information

The water solubility for the test item N-Methylformanilide was determined to be 4326 mg/L at 25°C.

Key value for chemical safety assessment

Water solubility:

4 326 mg/L

at the temperature of:

25 °C

Additional information

The water solubility determination of test item N-Methylformanilide (CAS No. 93-61-8) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of (N-Methylformanilide of 93-61-8) in water was determined to be 4326 mg/L at 25°C.

Thus based on obtained value the given chemical N-Methylformanilide is considered to be soluble in water.