Registration Dossier
Registration Dossier
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EC number: 229-186-3 | CAS number: 6424-76-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 17,18-dihydrodinaphtho[1',2',3':3,4;3'',2'',1'':9,10]perylo[1,12-efg][1,4]dioxocin-5,10-dione
- EC Number:
- 229-186-3
- EC Name:
- 17,18-dihydrodinaphtho[1',2',3':3,4;3'',2'',1'':9,10]perylo[1,12-efg][1,4]dioxocin-5,10-dione
- Cas Number:
- 6424-76-6
- Molecular formula:
- C36H18O4
- IUPAC Name:
- 17,18-dihydrodinaphtho[1',2',3':3,4;3'',2'',1'':9,10]perylo[1,12-efg][1,4]dioxocin-5,10-dione
- Test material form:
- solid: particulate/powder
- Details on test material:
- Vat Blue 16
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Herilan MRH-Haltung, Eggersmann KG, Germany
- Females (if applicable) nulliparous and non-pregnant: yes
- Weight at study initiation: male (mean): 180 g, female (mean): 160 g
- Fasting period before study: 15 - 20 h prior to application
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50%
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: dispersion used for application
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: 2-4 d, 7 d, 13 d after application
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Body weight:
- Male (mean): 266 g (+ 86 g gain)
Female (mean): 196 g (+ 36 g gain) - Gross pathology:
- Faeces stained blue.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on an oral limit test with 5000 mg/kg bw where no mortality or any other toxicological symptoms occured within 14 d after application (gavage) in male and female rats, the test item is not classifiable according to CLP criteria.
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