Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15.-18.06.1999
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar to guideline and scientifically acceptable
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report Date:
1999

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
yes
Remarks:
Report: datalacking; no 02 values given, duration only 24 hours
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Thiophaniumbromide

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
yes

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
24 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
28 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: 8.3-45 mg/L
Duration:
24 h
Dose descriptor:
EC100
Effect conc.:
> 120 - < 1 000 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
NOELR
Effect conc.:
3.4 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mobility

Any other information on results incl. tables

No mortality occurred in the control.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The EC50 24h for Thiophaniumbromide on Daphnia magna was determined to be 28 mg/L.
Executive summary:

Acute Toxicity Study in Daphnia magna with Thiophaniumbromide.

The study was performed under static test conditions. A range-finding test was followed by a limit test exposing Daphnia for a maximum of 24 hours to concentrations between 12.5 and 120 mg/l and a blank-control.

Thiophaniumbromide induced acute immobilisation of Daphnia magna at or below 120 mg/l. Hence, the EC50 24h was found to be 28 mg/L, the EC100 24h was >120 - <1000 mg/L.