Hydrocarbons, C8-10

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given:comparable to guidelines/standards.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)

EC Number:

919-446-0

IUPAC Name:

Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)

Details on test material:

- Name of test material (as cited in study report): Dilutine Moins Cinq (DM5)
- Composition of test material, percentage of components: Partially dearomatized white spirit, produced from low aromatic white spirit (LAWS) by hydrogenation; 3.5% aromatics
- Relative density 60/60°F = 0.765

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Ltd., Manston, Kent, UK
- Age at study initiation: 12 weeks
- Housing: 4 animals of one sex in each cage
- Fasting period before study:yes, overnight before dosing
- Diet (e.g. ad libitum): ad libitum, except during the fastinf period
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

No data

Doses:

1, 2, 4 and 8 mL/kg bw

No. of animals per sex per dose:

2

Control animals:

no

Details on study design:

- Duration of observation period following administration: 9 days

Statistics:

None

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality in all groups.

Clinical signs:

other: No data

Gross pathology:

No data

Other findings:

No data

Any other information on results incl. tables

No data

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information

Conclusions:

The oral LD50 for rats is > 8 mL/kg bw (~ 6000 mg/ kg bw).

Executive summary:

This study examined the acute toxicity of Dilutine M5 to rats via oral exposure. After an overnight fasting period, 2 female and 2 male rats were exposed to 1, 2, 4 or 8 mL/kg bw of undiluted test material by oral gavage, followed by a 9-day observation period. No rats died during the experiment. The oral LD50 for rats is > 8 mL/kg bw (~ 6000 mg/kg bw).