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EC number: 209-170-2 | CAS number: 557-34-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Carcinogenicity: Supporting information: Results of assays with Zinc Acetate show that the average number of tumors per animal was not significant (related to the control groups).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Link to relevant study records
- Endpoint:
- carcinogenicity
- Remarks:
- intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No specific test guideline was reported; however, a scientifically defensible approach was used to conduct the study. No GLP.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Animals/dose group: 20 mice (10 females and 10 males. Strain A)
Vehicle: 0.85% NaCl solution
Administration: i. p. injections
Animals are dosed: thrice-weekly (a total of 24 injections)
Positive carcinogen substance used in the study: Urethan
Duration of the study: 30 weeks - GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- Strain A
- Sex:
- male/female
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.85% NaCl solution
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 weeks
- Frequency of treatment:
- 24 injections applied thrice-weekly.
- Post exposure period:
- 22 weeks after the last injection all the animals were killed.
- Remarks:
- Doses / Concentrations:
360 mg/kg bw/day
Basis:
nominal conc.
0.85% NaCl solution - Remarks:
- Doses / Concentrations:
180 mg/kg bw/day
Basis:
nominal conc.
0.85% NaCl solution - Remarks:
- Doses / Concentrations:
72 mg/kg bw/day
Basis:
nominal conc.
0.85% NaCl solution - No. of animals per sex per dose:
- 10 females and 10 males per dose.
- Control animals:
- yes, concurrent no treatment
- yes, concurrent vehicle
- Positive control:
- Urethan
- Sacrifice and pathology:
- GROSS PATHOLOGY: No data
HISTOPATHOLOGY: Yes - Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Relevance of carcinogenic effects / potential:
- No tumors other than lung adenomas, 4 thymomas in mice treated, were observed in the controls.
Neoplasmas other than lung tumors were observed in the zinc acetate group. - Dose descriptor:
- other: maximum tolerated dose
- Effect level:
- 360 mg/kg bw (total dose)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: overall effects
- Remarks on result:
- other: Effect type: carcinogenicity (migrated information)
- Conclusions:
- Results of the assay shows that the average number of tumors per mouse induced by Zinc acetate was not significant (related to the control groups).
- Executive summary:
The zinc acetate carcinogenicity study was performed with strain A mice.
The results of the 3 dose concentrations tested (360, 180 and 72 mg/kg bw) shown that the average number of tumors per mouse were not significant (related to the control groups).
Reference
No tumors other than lung adenomas were observed in the controls:
Table 1: Lung tumors In vehicle-treated, urethan, and untreated A/Strong mice
Treatment |
Duration of experiment (wk) |
No. i.p, injections |
Survivors/ initial |
Mice with lung tumors (%) |
Av. no. of tumors/mouse |
0.65% NaCl solution |
30 |
24 |
19/20 |
37 |
0,42 ± 0.101 |
Tricaprylin |
30 |
24 |
18/20 |
44 |
0.50 ± 0.12 |
Urethan 20 mg |
30 |
1 |
18/20 |
100 |
21.6 ± 2.81 |
Untreated |
30 |
0 |
19/20 |
31 |
0.28 ± 0.07 |
Mean ± S.E.
Pulmonary tumors in A/strong mice treated with zinc acetate:
Table 2. Pulmonary tumors in A/strong mice treated with zinc acetate
Compound |
M.W. |
Vehicle" |
Duration of experi-ment (wk) |
No. of i.p. injec-tions |
Total dose (mg/kg of mouse) |
No, of ani-mals survi- |
Mice with lung tu-mors |
Av.no. of lung tumors/mouse |
p |
Zinc(II) Acetate |
219.49 |
s |
30 |
24 |
360 |
16/20 |
7 |
0.78 ± 0,22 |
NS |
|
|
|
|
|
160 |
18/20 |
8 |
0.67 ± 0.16 |
NS |
|
|
|
|
|
72 |
18/20 |
9 |
0.67 ± 0.16 |
NS |
aS: 0.85% NaCl solution bMean ± S.E. cNS: no significant
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
Additional information
Supporting information: Experimental data:
In the study reported by Stoner et al. (1976), a carcinogenicity study was performed with Zinc Acetate and strain A mice for 30 weeks. The results of the 3 dose concentrations tested (360, 180 and 72 mg/kg bw) shown that the average number of tumors per mouse were not significant (related to the control groups).
In the study reported by Rath et al. (1989) male and female rats received drinking water enriched with zinc acetate, 22.8 mmol/L, for 14 days. After this time of Zinc acetate exposure, a tumour cell suspension was injected into the tail vein of each of the 30 rats (no in control group). Rats were killed 36 days after the i.v. tumour cell application. The metastases developed in the lungs were counted. In both injected groups, the number of metastases on the surface is significantly correlated with the number of metastases on the cuts. Zinc ions seem to promote the emigration, implantation and outgrowth of circulating tumour cells.
In the control group (animals only treated with zinc-enriched drinking water for 380 days) no tumours were observed. The NOAEL was equal or higher than 5000 mg/L drinking water (for carcinogenicity).
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