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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1969
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: experimental details lacking; however, followed accepted methodology at time of testing

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report Date:
1969

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The test has been conducted prior to the current OECD guideline however, the LD50 calculation was based on an accepted method (Miller and Tainter).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
Material: GIV 3-1094 (Decenal trans)

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
The animals were fasted 12 hours prior to dosing.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Oral intubation
Doses:
100, 316, 1000, 3160, 5000 and 10000 mg/Kg
No. of animals per sex per dose:
6 groups of 6 animals (1 dose/animal)
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 7 000
Based on:
test mat.
Remarks on result:
other: as calculated by method of Miller and Tainter
Other findings:
principle toxic effect: Sedation

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on this test the LD50 was determined to be 7000 mg/kg bw.