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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1969
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: experimental details lacking; however, followed accepted methodology at time of testing
Qualifier:
no guideline available
Principles of method if other than guideline:
The test has been conducted prior to the current OECD guideline however, the LD50 calculation was based on an accepted method (Miller and Tainter).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
The animals were fasted 12 hours prior to dosing.
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Oral intubation
Doses:
100, 316, 1000, 3160, 5000 and 10000 mg/Kg
No. of animals per sex per dose:
6 groups of 6 animals (1 dose/animal)
Control animals:
no
Sex:
male
Dose descriptor:
LD50
Effect level:
> 7 000
Based on:
test mat.
Remarks on result:
other: as calculated by method of Miller and Tainter
Other findings:
principle toxic effect: Sedation
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on this test the LD50 was determined to be 7000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
7 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of acute toxicity – oral endpoint
The results obtained experimentally for acute oral toxicity were acquired prior to the establishment of accepted guidelines or Good Laboratory Practices (GLPs); however, the LD50 calculation was based on an accepted method (Miller and Tainter). The prediction obtained from OECD [Q]SAR Toolbox (v 3.3) supports the calculation from the experimentally derived data. Thus, it is acceptable to use the experimental LD50 value of 7000 mg/kg for the purposes of classification.

Justification for classification or non-classification

No classication needed as the experimentally-derived LD50 of 7000 mg/kg is supported by the OECD Toolbox prediction.