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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

Based on valid short-term daphnia studies for two closely related structural analogues, the daphnia 48 hour EC50 for (E)-dec-4-enal is estimated to be  1.17 - 1.54 mg/L. 

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
1.17 mg/L

Additional information

A study to assess short-term toxicity to aquatic invertebrates is not available for the registration substance, (E)-dec-4-enal. However, valid short-term daphnia studies exist for two analogue substances, decanal and nonanal. Read-across from these two analogue substances is considered to give a reliable estimate of the short-term toxicity of (E)-dec-4-enal to aquatic invertebrates and is justified based on the hypothesis that the target substance and two source substances will have similar ecotoxicological properties as a result of structural similarity, the same mode of action and similar physicochemical properties. A detailed justification for the proposed read-across is provided in the document "Aquatic Toxicity Read-Across Justification for (E)-DEC-4-ENAL", which is attached in section 13.

The study performed on decanal (ABC Study No. 65173) employed a semi-static test design with test medium renewal after 24 hours to keep the concentrations of the test item in the test media as constant as possible during the test period of 48 hours. As the test item is volatile, the test was performed using flasks covered with glass plates and completely filled with test medium to avoid losses of test substance. The study is considered reliable without restriction but because it is being used in a read-across approach it is rated reliability 2 (the maximum for read-across). It is GLP compliant, conducted according to OECD guideline 202 and using test material (99.1% pure) which is representative of the source substance. The study was valid (no control daphnids showed immobilization or other signs of disease or stress and the dissolved oxygen concentration was ≥3 mg/L in all test media), covered the required exposure duration of 48 hours and included sufficient dose levels to enable the relevant determination of potency. Thus the study is reliable and the results are adequate for the purpose of classification and labelling and/or risk assessment. The 48h EC50 was determined to be 1.17 mg/L (based on geometric mean measured concentrations)

The study performed on nonanal (T.R. Wilbury Study No. 2467-FF) was conducted under flow-through conditions. Measured concentrations of nonanal were steady during the test. The study is considered reliable without restriction but because it is being used in a read-across approach it is rated reliability 2 (the maximum for read-across). It is GLP compliant, conducted according to OECD guideline 202 and using test material (98% pure) which is representative of the source substance. The study was valid (no control daphnids showed immobilization or other signs of disease or stress and the dissolved oxygen concentration was≥3 mg/L in all test media),covered the required exposure duration of 48 hours and included sufficient dose levels to enable the relevant determination of potency.Thus the study is reliable and the results are adequate for the purpose of classification and labelling and/or risk assessment.The 48h EC50 was determined to be 1.54 mg/L (based on arithmetic mean measured concentrations).

The 48h EC50 results for the two source substances are similar and within the same environmental classification band. Used in a weight of evidence approach, they are considered to give a reliable estimate of the 48h EC50 for (E)-dec-4 -enal, which is a value of 1.17 - 1.54 mg/L.

The read-across is justified and considered adequate for the purposes of classification and labelling and/or risk assessment.