Registration Dossier
Registration Dossier
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EC number: 201-923-3 | CAS number: 89-61-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Skin irritation test of chemical 2,5-Dichloronitrobenzene (RTECS - CZ5260000)
- Author:
- RTECS® is a United States trademark owned and licensed under authority of the U.S. Government
- Year:
- 2 015
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances): Prehled Prumyslove Toxikologie; Organicke Latky; Volume(issue)/page/year: , 601,1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Skin irritation test of chemical 2,5-Dichloronitrobenzene was conducted on rabbit according to standard draize test.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-dichloro-2-nitrobenzene
- EC Number:
- 201-923-3
- EC Name:
- 1,4-dichloro-2-nitrobenzene
- Cas Number:
- 89-61-2
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,4-dichloro-2-nitrobenzene
- Reference substance name:
- 2, 5-Dichloronitrobenzene
- IUPAC Name:
- 2, 5-Dichloronitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2, 5-Dichloronitrobenzene
- Molecular formula (if other than submission substance): C6-H3-Cl2-N-O2
- Molecular weight (if other than submission substance): 192.001 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- no data
- Number of animals:
- no data
- Details on study design:
- The test was performed according to standard draize procedure.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Reversibility:
- no data
- Remarks on result:
- other: mildly
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Conclusions:
- The test was performed according to standard draize procedure.
- Executive summary:
Skin irritation test was conducted according to standard draize procedure for chemical 2,5-Dichloronitrobenzene.The test chemical was exposed to rabbit skin with dose concentration of 500 mg for 24-hrs.
Mild irritating effects were observed on skin of rabbit when exposed to test chemical 2,5-Dichloronitrobenzene for 24-hrs.
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