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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute Dermal toxicity study in rats for CAS no: 106-47-8
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute Dermal toxicity study for 4-Chloroaniline (106-47-8) in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloroaniline
EC Number:
203-401-0
EC Name:
4-chloroaniline
Cas Number:
106-47-8
Molecular formula:
C6H6ClN
IUPAC Name:
4-Chloroaniline
Details on test material:
- Name of test material (as cited in study report): 4-Chloroaniline
- Molecular formula : C6H6CIN
- Molecular weight : 127.57g/mole
- Substance type: organic
- Physical state: No data available
- Purity: No data available
- Impurities (identity and concentrations): No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report): 4-Chloroaniline
- Molecular formula : C6H6CIN
- Molecular weight : 127.57g/mole
- Substance type: organic
- Physical state: No data available
- Purity: No data available
- Impurities (identity and concentrations): No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
3200 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 3200 mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 was consider to be 3200 mg/kg bw, when rat was treated with 4-Chloroaniline by dermal application.
Executive summary:

The acute dermal toxicity study was conducted by using 4-Chloroaniline in rats at the concentration of 3200 mg/kg bw. 50% mortality was observed at 3200 mg/kg bw. Therefore, LD50 was consider to be 3200 mg/kg bw, when rat was treated with 4-Chloroaniline by dermal application.