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EC number: 203-998-8
CAS number: 112-70-9
An ocular irritation study of the test
chemical was conducted on six rabbits to assess its eye irritation
A single application of 0.1 ml of
undiluted alcohol was made into the conjunctival sac of the left eye of
each of six rabbits. The untreated eye served as the control. The
treated eye was closed for 30 seconds and eyes were not washed.
Observations for irritancy and possible systemic toxicity were made at
1, 4, and 24 hours and at 2, 3, 4, and 7 days. Where positive effects
persisted, observations were continued initially and at termination the
eyes were examined following instillation of 2 % sodium fluorescein
solution to detect any corneal lesions if not otherwise visible. Signs
of irritation exposure were graded and scored according to the method of
The median score was 4, 0 and 0 at 24
hours, 27 hours and day 7 respectively. Also the chemical caused little
irritation in most of the animals, but persistent corneal opacity in one
rabbit. Thus on the basis of scores and observed effects the test
chemical was considered as moderately irritating to the rabbits’ eye.
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