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EC number: 203-998-8
CAS number: 112-70-9
Table: Acute Oral toxicity of
a- LD50 value was estimated, since
mortality pattern was not suitable for analysis.
Acute oral toxicity study was
conducted by using test chemical in groups of 5 male Sprague-Dawley rats
at the concentration ranging from 0.032 to 10.0 ml/kg body weight. The
given test chemical was dissolved in a corn oil suspension or in
undiluted form. The animals had been fasted for 3 to 4 hours prior to
the study and were group-housed, with water and feed freely available
after dosing. Observations for signs of toxicity were made frequently on
the day of administration and daily thereafter for a period of 7 to 14
days. Gross necropsy examinations were performed on all animals that
died or were killed. The mortality data were analyzed by the moving
average of Horn or the method of Litchfield and Wilcoxon. The results
have been converted to weight units by means of the specific gravity.
LD50 was estimated, since mortality pattern was not suitable for
analysis. 50% Mortality observed at 4750 mg/kg bw.The principal signs of
effect were central nervous system depression and labored respiration.
The depression included inactivity, ataxia, limb sprawling, depressed
righting and placement reflexes, prostration, and coma.Gross necropsy
revealed some evidence of gastrointestinal irritation. Therefore, the
acute oral toxicity dose (LD50) was considered to be 4750 mg/kg bw, when
groups of 5 male Sprague-Dawley rats were treated with the test chemical via
oral gavage route.
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