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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from Chemidplus report

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Chemidplus report for CAS 118-47-8
Author:
U.S.national library of medicine
Year:
2016
Bibliographic source:
ChemIDplus,A TOXNET DATABASE, Last updated: 21 June 2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: The data is from chemid plus
Principles of method if other than guideline:
Acute oral toxicity of chemical Pyrazolone T was determined.
GLP compliance:
not specified
Test type:
other: not reported

Test material

Constituent 1
Chemical structure
Reference substance name:
5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
EC Number:
204-254-5
EC Name:
5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
Cas Number:
118-47-8
Molecular formula:
C10H8N2O6S
IUPAC Name:
5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
Constituent 2
Reference substance name:
Pyrazolone T
IUPAC Name:
Pyrazolone T
Details on test material:
- Name of test material: 5-Oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
- Molecular formula: C10H8N2O6S
- Molecular weight: 284.2472 g/mol
- Smiles notation: c1cc(ccc1N2C(=O)CC(=N2)C(=O)O)S(=O)(=O)O
- InChl: 1S/C10H8N2O6S/c13-9-5-8(10(14)15)11-12(9)6-1-3-7(
4-2-6)19(16,17)18/h1-4H,5H2,(H,14,15)(H,16,17,18)
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 22 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Lethality of test chemical
Mortality:
No data available
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.
Executive summary:

Acute oral toxicity test was conducted on rat to evaluate the lethargic concentration of chemical Pyrazolone T.

The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.