Registration Dossier
Registration Dossier
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EC number: 202-947-7 | CAS number: 101-50-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.:101-50-8
- Author:
- Danish (Q)SAR Database
- Year:
- 2 016
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.
Materials and methods
- Principles of method if other than guideline:
- The data predicted using the Danish (Q)SAR Database
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-aminoazobenzene-3,4'-disulphonic acid
- EC Number:
- 202-947-7
- EC Name:
- 4-aminoazobenzene-3,4'-disulphonic acid
- Cas Number:
- 101-50-8
- Molecular formula:
- C12H11N3O6S2
- IUPAC Name:
- 4-aminoazobenzene-3,4'-disulphonic acid
- Details on test material:
- - Name of test material: 4-aminoazobenzene-3, 4’-disulphonic acid- Molecular formula: C12H11N3O6S2- Molecular weight: 357.36 g/mol- Substance type: Organic-SMILES: c1(cc(c(N)cc1)S(O)(=O)=O)\N=N\c1ccc(S(O)(=O)=O)cc1
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other: estimated
- Basis:
- mean
- Remarks on result:
- other: non irritating
Any other information on results incl. tables
| Exp | Battery | CASE Ultra | Leadscope | SciQSAR |
Severe Skin Irritation in Rabbit |
| NEG_IN | INC_OUT | NEG_IN | NEG_IN |
Allergic Contact Dermatitis in Guinea Pig and Human | NA | POS_IN | POS_IN | POS_OUT | POS_IN |
Respiratory Sensitisation in Humans |
| POS_IN | POS_IN | POS_IN | POS_IN |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin irritation was estimated to be not irritating on rabbits for 4-aminoazobenzene-3,4'-disulphonic acid.
- Executive summary:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin irritation was estimated to be not irritating on rabbits for 4-aminoazobenzene-3,4'-disulphonic acid. Thus it can be concluded that the substance 4-aminoazobenzene-3,4'-disulphonic acid has negative skin irritation effects and it can be classified as not irritating to skin irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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