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EC number: 250-797-6
CAS number: 31775-16-3
- no marked reductions in viability of cells treated with the test item
in the presence or absence of metabolic activation
- vehicle controls were within the normal range (10 - 125 x 10E-6)
- positive controls gave marked increases in mutant frequency,
demonstrating that the test system was operating satisfactorily
- the test item did not induce any statistically significant or dose
related increase in mutant frequency
- experiment 1 and 2 gave concordant results
Mouse Lymphoma cells (L5178Y TK+/-) were treated with the test substance
at five concentrations in the range of 62.5 to 1000 µg/ml. A heavy
precipitate of the test substance was noted at all dose levels. The
solvent control gave mutant frequencies within the normal range. The
positive controls gave marked increases in the mutant frequency, both in
the presence or absence of metabolic activation, indicating the
satisfactory performance of the test system. The test substance demonstrated
no statistically significant or dose related increases in mutant
frequency at any dose level, either with or without metabolic
activation, thus indicating that the test item is not mutagenic under
the conditions tested.
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