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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 4 - July 23, 1994
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed according to OECD guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994
Report Date:
1994

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
standard fat
Remarks:
HB 307
Solubility:
0.006 other: g/kg
Temp.:
37 °C
Details on results:
The preliminary test indicated the fat solubility to be 1.74 x 10-3 g/kg.
For results of the main test, see below.

Any other information on results incl. tables

Results of the main test:

Sample number

Initial temperature
(°C)

Initial shaking

time (hours)

Final
tempe­­rature (°C)

Final shaking

time (hours)

Concentration
(g/kg)

1

30

1½

37

3

5.75 x 10-3

2

30

1½

37

3

5.59 x 10-3

3

50

1½

37

3

7.01 x 10-3

4

50

1½

37

3

6.98 x 10-3

5

30

1¼

37

24¼

5.30 x 10-3

6

30

1¼

37

24¼

5.53 x 10-3

7

50

1¼

37

24¼

5.96 x 10-3

8

50

1¼

37

24¼

5.93 x 10-3

Mean concentration = 6.01 x 10-3 g/kg

Standard deviation = 6.47 x 10-4

Applicant's summary and conclusion

Conclusions:
The fat solubility of the test item is 6.01 x 10-3 g/kg at 37.0 °C.
Executive summary:

The fat solubility of test substance has been determined in a guideline study to be 6.01 x 10-3 g/kg at 37.0 ± 0.5 °C.