Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-870-9 | CAS number: 100-61-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
As reported in SCOEL/SUM/178 of December 2012 for N-methylaniline no data were available regarding the absorption, distribution, metabolism or excretion of the substance in the human.
The dermal application of the substance in the rabbit is lethal (see Treon et all, J Ind Hyg Toxicol, 31:1-20, 1949) and it is expected that N-methylaniline is ready absorbed through the skin. As reported in HSDB Report of N-methylaniline with reference to Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. 421 the substance yields aniline and p-methylaminophenol in rabbit.
In dog after intravenous injection N-methylaniline is quickly transformed in nitrosobenzene (see Kiese et all, Naturwissen-schaften 46:384, 1959 mentioned in SCOEL/SUM/178 of December 2012of N-methylaniline).
N-methylaniline was quickly excreted in urine after intraperitoneal administration in rat (28 mg of NMA/kg and 85% excreted in urine in 24h -see Greim et all, Gesundheitsschädliche Arbeitsstoffe, Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten, Loseblattsammlung, 23. Lfg. DFG, Deutsche Forschungsgemeinschaft, WILEY-VCH Verlag, Weinheim, 1996 mentioned in SCOEL/SUM/178 of December 2012 of N-methylaniline).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
