Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Emergency measure - Inhalation: Remove to fresh air. Symptomatic treatment. Obtain immediate medical attention.
Emergency measure - Eyes: Wash thoroughly with water and continue for at least 15 minutes. Seek medical attention.
Emergency measure - Skin: Remove contaminated clothing and launder before reuse.
Thoroughly wash all affected areas with soap and water. Seek medical attention.
Emergency measure - Ingestion: Seek immediate medical attention.

Fire-fighting measures

Recommended extinguishing agent: Water, foam, powder or carbon dioxide.

Product arising from burning: Noxious fumes (eg carbon and nitrogen oxides and chlorine containing compounds).

Product determined by test: N

Protective equipment: Full protective clothing and a self-contained breathing apparatus must be worn.

Accidental release measures

Emergency measures in case of spillage: Ensure suitable protective clothing during removal of spillages.

Damp down and sweep up into a container for disposal. Wash the spillage area with water.

Disposal should be in accordance with local, state or national legislation.

Handling and storage

Handling: The substance should be stored, handled and used under conditions of good industrial hygiene and in conformity with any local regulations in order to avoid exposure by skin and eye contact, ingestion and inhalation.

Storage: Keep container tightly closed in a cool dry place.

Packaging of the substance and or preparation: Polythene lined fibre board kegs.

Transport information

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Marine transport (UN RTDG/IMDG)

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Air transport (UN RTDG/ICAO/IATA)

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Special provisions / remarks
Transport code: None
Transport: Avoid crushing the containers.
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Exposure controls / personal protection

Occupational Hygiene Air
Monitoring Methods
An occupational/industrial hygiene monitoring method has been developed for this material. For
advice on suitable monitoring methods, seek guidance from a qualified environment, health and
safety professional.
Exposure Controls
This material has been assigned to GlaxoSmithKline Occupational Hazard Category 3 with a
hygiene guide of 10 - <100 mcg/m3. An Exposure Control Approach (ECA) is established for
operations involving this material based upon the OEL/Occupational Hazard Category and the
outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for
more information about how ECA's are assigned and how to interpret them.
Open handling is not recommended. Consider segregating operations, use of enclosures and
sealed transfer systems.
Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a
means of removing material incidentally released.
Entry to the working area should be controlled. Doors with interlocks may be needed for materials
airlocks and locker rooms. Only equipment and supplies necessary for job activities should be
taken into working area.
Eye Protection
Wear approved cover goggles if eye contact is possible. In addition, a face shield is
The selection of gloves for a specific activity must be based on the material's properties and on
possible permeation and degradation that may occur under the circumstances of use. Glove
selection must take into account any solvents and other hazards present. Potential allergic
reactions can occur with certain glove materials (e.g. Latex) and therefore these should be
avoided. Care must be exercised if insufficient data are available and further guidance should be
sought from your local EHS department.
If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air
concentrations present, required protection factor as well as hazards, physical properties and
warning properties of substances present. RPE should provide full face protection. Follow local
regulations for respirator use in the workplace.
Other Equipment or
Consider control procedures for maintenance, cleaning and emergencies. Eye wash and shower
stations should be available. Wear appropriate clothing to avoid skin contact.

Stability and reactivity

Danger other than fire: None reported.

Chemical reaction with water: None reported.

Dust explosion: There is a potential for dust explosion of this organic powder when it becomes airbourne. However, appropriate handling and storage procedures are used to minimise the risk of electrostatic discharge.

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: Handling of the substance will be by trained operators, and will be kept to a minimum.

Discharge to the environment will be minimal. Recovery from minor spillages or accidental discharge is not economically or technically feasible, and such waste material wiil be disposed of by incineration. In principle, it may be possible to recover larger spillages of uncontaminated material for subsequent use.

Industry - Possibility of neutralisation: The notification tests have shown that the substance is toxic, an eye irritant, a skin sensitiser and dangerous for the environment.

No chemical treatment is practicable to neutralise the hazardous health properties.

The potential dust storage hazard will be minimised by appropriate handling and storage.

No chemical treatment is practicable to neutralise the hazardous environmental properties.

Industry - Possibility of destruction: controlled discharge: Contaminated containers or spillages of solutions mixed with inert material (eg. sand or soil) should be disposed of by incineration in accordance with local regulations.

Industry - Possibility of destruction - incineration: The substance can be disposed of by incineration by burning under controlled conditions at a licensed waste treatment processor in accordance with local regulations. Stack gases should be scrubbed, because noxious fumes (eg. carbon and nitrogen oxides and chlorine-containing compounds) could be

Industry - Possibility of destruction - water purification: The substance will not normally be discharged directly to the sewage system or the aqueous environment.

Public at large - Possibility of recovery/recycling: Not applicable

Public at large - Possibility of neutralisation: Not applicable

Public at large - Possibility of destruction: controlled discharge: Not applicable

Public at large - Possibility of destruction - incineration: Not applicable

Public at large - Possibility of destruction - water purification: Not applicable

Public at large - Possibility of destruction - others: Not applicable