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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Study completion date: 20 Feb 1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Version / remarks:
CIBA Internal Method A-11.
Deviations:
not specified
GLP compliance:
no
Specific details on test material used for the study:
Name: FAT 36156/A
Purity: 18.04 %
Analytical monitoring:
no
Vehicle:
yes
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
Zebrafish: Danio rerio
Replicates: 10 per test concentration
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Test temperature:
23 °C
Nominal and measured concentrations:
Nominal concentrations: 100, 300 and 1000 mg/L
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
At 100 mg/L: 10/10 fish survived at 96 h. No mortality was observed.
At 300 mg/L: 9/10 fish survived at 96 h.
At 1000 mg/L: 5/10 fish survived at 96 h.
Validity criteria fulfilled:
not specified
Conclusions:
The LC50 of FAT 36156/A in this fish acute toxicity test was determined to be greater than 1000 mg/L.
Executive summary:

The acute fish toxicity test was performed according to CIBA internal method A-11 which is equivalent or similar to OECD Guideline 203.


10 Zebra fish were used in this test at each dose level, and were tested at these different following concentrations: 100, 300 and 1000 mg/L.


Following observations were reported;


At 100 mg/L: 10/10 fish survived at 96 h. No mortality was observed.


At 300 mg/L: 9/10 fish survived at 96 h.


At 1000 mg/L: 5/10 fish survived at 96 h.


 Based on the findings of this study, the following 96 h LC values were noted when Zebra fish were exposed to test substance FAT 36156/A in a static system:


LC0 =1000 mg/L


LC50 >1000 mg/L


LC100 > 1000 mg/L.

Description of key information

The acute fish toxicity test was performed according to CIBA internal method A-11 which is equivalent or similar to OECD Guideline 203. 10 Zebra fish were used in this test at each dose level and were tested at these different following concentrations: 100, 300 and 1000 mg/L as in the pre-test.


Following observation was observed;


At 100 mg/L: 10/10 fish survived at 96 h. No mortality was observed.


At 300 mg/L: 9/10 fish survived at 96 h.


At 1000 mg/L: 5/10 fish survived at 96 h.


 


Based on the findings of this study, the following 96 h LC values were noted when Zebra fish were exposed to test substance FAT 36156/A in a static system:


LC0 =1000 mg/L


LC50 >1000 mg/L


LC100 >1000 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
1 000 mg/L

Additional information