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EC number: 218-044-6 | CAS number: 2042-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Assessing Applicability Domains of Toxicological QSARs: Definition, Confidence in Predicted Values, and the Role of Mechanisms of Action
- Author:
- Terry W. Schultz, Mark Hewitt, Tatiana I. Netzeva, Mark T. D. Cronin
- Year:
- 2 007
- Bibliographic source:
- QSAR Comb. Sci. 26, 2007, No. 2, 238 – 254
- Reference Type:
- review article or handbook
- Title:
- Accurate Prediction of Aquatic Toxicity of Aromatic Compounds Based on Genetic Algorithm and Least Squares Support Vector Machines
- Author:
- Beilei Lei, Jiazhong Li, Huanxiang Liu and Xiaojun Yao
- Year:
- 2 008
- Bibliographic source:
- QSAR Comb.Sci. 27, 2008, No.7, 850 – 865
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- CAS Number: 2042-14-0
SMILES : c1c(O)ccc(C)c1N(=O)(=O)
CHEM : 3-Nitro-p-cresol
MOL FOR: C7 H7 N1 O3
MOL WT : 153.14
Constituent 1
Test organisms
- Test organisms (species):
- Tetrahymena pyriformis
Results and discussion
Effect concentrations
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 27.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
Any other information on results incl. tables
Population growth impairment testing with the protozoa, T. pyriformis was conducted following the protocol of T. Wayne Schultz et al. [Schultz, T.W. TETRATOX: Tetrahymena pyriformis population growth impairment endpoint - a surrogate for fish lethality. Toxicol. Mech. Meth. 1997, 7, 4, 289–309.]. This static assay uses population density quantified spectrophotometrically at 540 nm as its endpoint. The test protocol allows for eight to nine cell cycles in controls. The testsubstance was tested separately three times.
For each test, two controls were used to provide a measure of the acceptability by indicating the suitability of the medium
and test conditions as well as a basis for interpreting data from other treatments. The first control had no test substance but was inoculated with T. pyriformis. The other was a blank and had neither test substance nor ciliates.
Each assay consisted of six to ten different concentrations with duplicate flasks at each concentration. Only replicates with control-absorbence values >0.60 but <0.90 were used in the analyses.
Toxic potency was quantified as the 50% Growth Inhibitory Concentration (IGC50). The IGC50 was determined for
the test substance by Probit Analysis using the Statistical Analysis System (SAS) software with the Y-values being absorbencies
normalized as percentage of control and the X-values being toxicant concentrations in mg/L. Toxicity data were converted to mmol/L.
Applicant's summary and conclusion
- Executive summary:
A test with Tetrahymena pyriformis according to Population growth impairment assay.
The 50% growth inhibitory concentration (IC50) is determined by Probit Analysis of Statistical Analysis System (SAS). ).
An EC50 of 27.9 mg/L related to the nominal concentration of 3-Nitro-p-cresol was observed.
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