Registration Dossier
Registration Dossier
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EC number: 436-690-9 | CAS number: 220727-26-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert judgement
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented statement meeting basic scientific principles
Data source
Reference
- Reference Type:
- other: Expert judgement
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
- Objective of study:
- toxicokinetics
Test material
- Details on test material:
- - Name of test material (as cited in study report): Y-15099
Constituent 1
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Y-15099 is predicted to be bioavailable.
- Type:
- distribution
- Results:
- General tissue accumulation is possible, but the potential is expected to be low.
- Type:
- metabolism
- Results:
- Y-15099 has been identified as a potent skin sensitizer. This result confirms that the compound or its metabolites or hydrolysis products are capable of binding to proteins.
- Type:
- excretion
- Results:
- For the most metabolites biliary excretion is more likely than renal excretion.
Applicant's summary and conclusion
- Conclusions:
- low bioaccumulation potential based on study results
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