2,4,6-trichloroaniline

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data from handbook or collection of data

Data source

Reference

Reference Type:

other: Authoritative database

Title:

Toxicity of test chemical

Author:

IFA GESTIS

Year:

2018

Bibliographic source:

GESTIS Substance Database

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

An eye irritation study was conducted to determine the adverse effects caused by the test chemical.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,4,5-trichloroaniline

EC Number:

211-254-9

EC Name:

2,4,5-trichloroaniline

Cas Number:

636-30-6

Molecular formula:

C6H4Cl3N

IUPAC Name:

2,4,5-Trichloraniline

Details on test material:

- Name of test material (as cited in study report): 2,4,6 trichloroaniline
- Molecular formula (if other than submission substance): C6-H4-Cl3-N
- Molecular weight (if other than submission substance): 196.464
- Substance type: organic
- Physical state: solid
- Purity: > 99%
- Impurities (identity and concentrations): no data available

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

Not specified

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

100% (undiluted)

Duration of treatment / exposure:

72 hours

Observation period (in vivo):

72 hours

Number of animals or in vitro replicates:

Not specified

Details on study design:

- Area of exposure: conjunctival sac

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

72 h

Reversibility:

fully reversible within: 72 h

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

The chemical produced reddening and swelling of the conjunctiva for a short time. Only a few animals showed slight opacity of the cornea and this was reversible after 72 hours (as a rule).

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

The test material was considered to be not irritating to the eyes of treated rabbits.

Executive summary:

An eye irritation study was conducted to determine the adverse effects caused by the test chemical.

 

When the undiluted chemical was instilled into the eyes of each rabbit, the chemical producedreddening and swelling of the conjunctiva for a short time. Only a few animals showed slight opacity of the cornea and this was reversible after 72 hours (as a rule).

 

Since the observed effects were not persisted during the observation period, the test chemical was considered to be not irritating to the eyes of rabbits.