2,4-Pyrimidinediamine, 6-chloro-, 3-oxide

Stability: thermal, sunlight, metals

Administrative data

Endpoint:

thermal stability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Q2-Q3 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

-

Deviations:

no

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,4-Diamino-6-chloropyrimidine-3-oxide

EC Number:

609-076-5

Cas Number:

35139-67-4

Molecular formula:

C4H5ClN4O

IUPAC Name:

2,4-Diamino-6-chloropyrimidine-3-oxide

Test material form:

solid

Remarks:

white/beige solid

Specific details on test material used for the study:

- Analytical purity: > 99%- Lot/batch No.: 0160405- Expiration date of the lot/batch: 21/02/2018

Results and discussion

For thermal stability study

Test substance thermally stable:

yes

Remarks:

In accrodance with the OECD TG 113, the test item is considered thermally stable, as no decompostion was observed at temperature below 150°C.

Operating temperature

Key result

Operating temp.:

ca. 187.7 °C

Remarks on result:

other: During the DSC run one exothermic event was observed. The event was very sharp with a high energy. The energy was with 1339.52 J/g above the threshold of -500 J/g. Therefore, further tests for explosive properties have to be performed.

Sublimation:

no

Transformation products:

not measured

Any other information on results incl. tables

Safety pre-test 1

Beaten with a hammer on the anvil no reaction could be observed.

Heated on a magnesia groove over a Bunsen burner the test substance immediately carbonised under smoke.

Safety pre-test 2

No deformation of the crucible was observed. The mass of the crucible was recorded with 620.06 mg. A black residue was left in the crucible. The sealing was grey-black coloured.

Calibration

After calibration with indium and zinc the measurement of indium yielded the following values:

Values DSC Indium

Expected Meltingpoint	Measured Meltingpoint	Expected Energy	Measured Energy	Assessment
156.6 ± 1.0°C	156.43 °C	28.45± 1.0J/g	28.40J/g	OK

 

The measurement of indium after calibration met the validity criteria.

DSC Screening of the Test Item

A sharp exothermic event was observed at 187 .71 °C.

Evaluation andResult

During the DSC run one exothermic event was observed. The event was very sharp with a high energy. The energy was with 1339.52 J/gabove the threshold of -500 J/g. Therefore, further tests for explosive properties have to be performed.

Without further tests, the test item cannot be classified.

The measurement of indium after calibration met the validity criteria. Therefore, the result of the study is considered valid.

 

Applicant's summary and conclusion

Conclusions:

During the DSC run one exothermic event was observed at 187.71°C. The event was very sharp with a high energy. The energy was with 1339.52 J/g above the threshold of -500 J/g. Therefore, further tests for explosive properties have to be performed. In accordance with the OECD TG 113, the test item is considered thermally stable, as no decompostion was observed at temperature below 150°C.The measurement of indium after calibration met the validity criteria. Therefore, the result of the study is considered valid.

Executive summary:

The thermal stability of the test item has been determined with a not-GLP compliant study, following the standard guideline OECD TG 113. During the DSC run one exothermic event was observed at 187.71°C. The event was very sharp with a high energy. The energy was with 1339.52 J/g above the threshold of -500 J/g. Therefore, further tests for explosive properties have to be performed. In accordance with the OECD TG 113, the test item is considered thermally stable, as no decomposition was observed at temperature below 150°C.

The measurement of indium after calibration met the validity criteria. Therefore, the result of the study is considered valid.