Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

There are no reliable studies that investigate the potential for trimethoxysilane to cause adverse effects on fertility, therefore a reliable oral OECD 422 study on the structural analogue, methyltrimethoxysilane, has been used. In addition there is a 90 day rat inhalation study on methyltrimethoxysilane that did not show any adverse treatment-related effects on the reproductive organs up to an exposure concentration of 8900 mg/m3.


Short description of key information:
No studies have been conducted with trimethoxysilane for reproductive toxicity. Since the 90 day inhalation study tested very low concentrations of trimethoxysilane, it is appropriate to read-across from the structural analogue, methyltrimethoxysilane, for which there is an oral OECD 422 study. In this study reproductive effects were not observed up to a dose of 1000 mg/kg bw/day.

Effects on developmental toxicity

Description of key information
No studies have been conducted with trimethoxysilane for developmental toxicity. Since the 90 day inhalation study tested very low concentrations of trimethoxysilane, it is appropriate to read-across from the structural analogue, methyltrimethoxysilane, for which there is an oral OECD 422 study. In this study developmental effects were not observed up to a dose of 1000 mg/kg bw/day. 
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

There are no reliable studies that investigate the potential for trimethoxysilane to cause adverse effects on fertility, therefore a reliable oral OECD 422 study on the structural analogue, methyltrimethoxysilane, has been used.

Justification for classification or non-classification

The available data on the structural analogue, methyltrimethoxysilane, do not suggest that trimethoxysilane should be classified for effects on reproduction and development.