Registration Dossier

Administrative data

Description of key information

In the key skin irritaton study (BRRC, 1988), conducted using a protocol similar to OECD 404, undiluted trimethoxysilane was corrosive to the skin of rabbits (strain not given) after a four hour exposure, under occlusive conditions. The key eye irritation study (BRRC, 1988), which was similar to OECD 405, showed undiluted trimethoxysilane to be moderately irritating to the eyes of rabbits (strain not given). Acute inhalation and repeated dose inhalation studies indicate that this test substance is irritating/corrosive to the respiratory tract. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

For skin irritation the most reliable study was used as the key study. All other studies were reliability 4. For eye irritation there were three reliability score 2 studies. The most recent of these was selected as the key study. Most studies were supportive of the key study findings. Where they were not, there were methodological or reporting deficiencies.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: moderately irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Trimethoxysilane is labelled as 'R34: Causes burns' and 'R37: Irritating to the respiratory tract' under Directive 67/548/EEC, and the proposed hazard class under Regulation 1272/2008 is 'Skin Corr. 1C'. , and hence 'H314: Causes severe skin burns and eye damage'. The serious damage to eyes is implicit for substances classified as Category 1 for skin corrosion.