Registration Dossier

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original study was not reviewed.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969

Materials and methods

Objective of study:
toxicokinetics
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Doses / concentrations
Remarks:
Doses / Concentrations:
2450 mg/kg trimethoxysilane or 2000 mg/kg methanol

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 3rd:

Metabolite characterisation studies

Metabolites identified:
yes

Any other information on results incl. tables

"In rats treated with the silane, the methanol level was
high 1 hr after treatment, indicating rapid absorption. The
level was still elevated at 24 hr, indicating sustained
release of methanol.  Animals treated with methanol
exhibited a much lower methanol level at 24 hr, showing that
methanol alone is metabolized fairly rapidly.  Silicon
levels after trimethoxysilane administration were elevated
at 1 hr and even higher at 24 hr, indicating continuous
release of this element."

Applicant's summary and conclusion