Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: human accidental exposure information
Adequacy of study:
weight of evidence
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: 4b The result is sourced from secondary literature (IUCLID 2007 data set). The original reference was not available for review and no further information is available.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Clinical and Experimental Investigation of Ocular Damage Caused by Trimethoxysilane
Author:
Tamura, A., Yuri, H., Maruyama, H. and K. Maruyama
Year:
1968
Bibliographic source:
Jap Opthalmol So 72(1):|40-47. Cited in AIHAJ Workplace Environmental Exposure Level Guides: Trimethoxysilane (1997).
Reference Type:
publication
Title:
Rationale Document for Trimethoxysilane. Union Carbide.
Author:
Plevan RE
Year:
1991
Bibliographic source:
Cited in AIHAJ (1997) Workplace Environmental Exposure Level Guides: Trimethoxysilane (1997)

Materials and methods

Study type:
poisoning incident
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): No data
No information on test substance.

Method

Subjects:
Six workers exposed.
No other data
Route of exposure:
inhalation
Reason of exposure:
accidental
Exposure assessment:
not specified

Results and discussion

Clinical signs:
Six workers engaged in purification of the test substance experienced irritation, pain, lacrimation and disturbance of vision 8-12 hours after work. Eye examinations revealed conjunctival hyperemia, chemosis and desquamation of the corneal epithelium. Healing took 20-90 days. Two of the six workers developed a sore throat and four suffered bronchitis or bronchopneumonia.

Applicant's summary and conclusion

Conclusions:
In a short summary (reliability score 4) of a human accidental incident six workers engaged in purification of the test substance experienced irritation, pain, lacrimation and disturbance of vision 8-12 hours after work. Eye examinations revealed conjunctival hyperemia, chemosis and desquamation of the corneal epithelium. Healing took 20-90 days. Two of the six workers developed a sore throat and four suffered bronchitis or bronchopneumonia.
Executive summary:

In a short summary (reliability score 4) of a human accidental incident six workers engaged in purification of the test substance experienced irritation, pain, lacrimation and disturbance of vision 8-12 hours after work. Eye examinations revealed conjunctival hyperemia, chemosis and desquamation of the corneal epithelium. Healing took 20-90 days. Two of the six workers developed a sore throat and four suffered bronchitis or bronchopneumonia.