Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1952

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cobalt dihydroxide
EC Number:
244-166-4
EC Name:
Cobalt dihydroxide
Cas Number:
21041-93-0
Molecular formula:
CoH2O2
IUPAC Name:
cobalt(2+) dihydroxide
Details on test material:
No further details given.

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: not stated
- Age at study initiation: "young"
- Weight at study initiation:200-300g
- Fasting period before study: yes, no period given
- Housing: not stated
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: not stated

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
propylene glycol
Doses:
250, 500, 1000, 2000, 4000, 8000mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no
Statistics:
nmot reported

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD0
Effect level:
500 mg/kg bw
Based on:
test mat.
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 060 mg/kg bw
Based on:
test mat.
95% CL:
> 680 - < 1 660
Sex:
male/female
Dose descriptor:
LD100
Effect level:
4 000 mg/kg bw
Based on:
test mat.
Mortality:
yes
Clinical signs:
other: diarrhea, ruffled fur, debilitation
Gross pathology:
not conducted

Any other information on results incl. tables

Cobalt hydrate powder

fasted male and female albino rats

weights 200 -300 grams

vehicle: polypropylene glycol

Dose level

No. animals

Number of days and deaths

total

 

1

2

3

4

5

6

7

8

9

10

11

12

13

14

survivals

Deaths

250

5

 

 

 

 

 

 

 

 

 

 

 

 

 

 

5

0

500

5

 

 

 

 

 

 

 

 

 

 

 

 

 

 

5

0

1000

5

 

 

 

 

1

 

 

 

1

1

 

 

 

 

2

3

2000

5

 

 

 

 

1

1

 

 

1

1

 

 

 

 

1

4

4000

5

 

 

 

4

 

 

 

 

 

1

 

 

 

 

0

5

8000

5

 

2

 

2

1

 

 

 

 

 

 

 

 

 

0

5

 

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The following LD50 value was determined for cobalt dihydroxide:
LD50 (combined male and female rats): 1060 mg/kg bw
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is classified as Category 4.