Registration Dossier
Registration Dossier
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EC number: 215-609-9 | CAS number: 1333-86-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- IARC Monograph vol 93
- Year:
- 2 006
- Bibliographic source:
- IARC publication
- Report date:
- 2006
Materials and methods
Test material
- Reference substance name:
- Carbon black
- EC Number:
- 215-609-9
- EC Name:
- Carbon black
- Cas Number:
- 1333-86-4
- Molecular formula:
- C
- IUPAC Name:
- carbon
- Test material form:
- solid: granular
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Duration of treatment / exposure:
- 12 weeks
Results and discussion
Any other information on results incl. tables
ln rats exposed to carbon black by inhalation, hprt mutant frequency was elevated in type II celIs folIowing a 12-week exposure.
In two of five studies, carbon black induced an increase in DNA adducts in the peripheral lung tissue of rats after inhalation exposure
Applicant's summary and conclusion
- Conclusions:
- Most of assays for mutagenicity were negative for carbon black
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