Registration Dossier
Registration Dossier
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EC number: 500-236-9 | CAS number: 68920-66-1 1 - 2.5 moles ethoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- limited reporting; no details on test animals and environmental conditions
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Alcohols, C16-18 and C18-unsatd., ethoxylated
- EC Number:
- 500-236-9
- EC Name:
- Alcohols, C16-18 and C18-unsatd., ethoxylated
- Cas Number:
- 68920-66-1
- Molecular formula:
- not applicable, UVCB
- IUPAC Name:
- Alcohols, C16-18(even numbered) and C18 unsaturated, ethoxylated < 2.5 EO
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 154 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 2% solution
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 10 mL/ kg bw
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: prior to administration, 48 h, 1 week and 2 weeks post administration
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No clinical signs of toxicity were observed after administration or during the 14 day observation period.
- Gross pathology:
- No gross abnormalities were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
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