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EC number: 208-762-8
CAS number: 540-97-6
Table 1. Results of analysis of test media
Table 2. Test results
90 day NOEC ≥14 μg/l, measured, Oncorhynchus mykiss
(Springborn Smithers 2009f). This is above the water solubility of the
registration substance D6 (5.1 µg/l); therefore, D6 is not expected to
show toxicity at its limit of solubility.
Reliable test results are available for
long-term toxicity to fish. A 90-day Read-Across NOEC of ≥14
µg/L has been determined for the effects of the read-across
substance decamethylcyclopentasiloxane (D5, CAS 541-02-6) on hatching
and larval survival and growth of Oncorhynchus mykiss. The
results were obtained from an early-life stage: reproduction,
(sub)lethal effects flow-through test, conducted in accordance with OECD
Guideline 210 and in compliance with GLP (Springborn Smithers 2009f). In
view of the exposure regime it is likely that the test organisms
were exposed primarily to the tested substance rather than its
The read-across justification is discussed in the Ecotoxicological
Information endpoint summary in Section 6 of IUCLID, Section 7.0 of the
CSR and in the siloxanes category supporting report (PFA 2017).
This is supported by a 49-day NOEC of >4.4
μg/l for the effects of the registration substance, D6, on mortality of
adult fish (Pimephales promelas) (Dow Corning 2005). No other
effects were assessed in this test, which was primarily designed to
The conclusion of no effects at the limit of
solubility is further supported by a peer-reviewed study by Redman et
al. (Redman 2012). A tissue based risk assessment was performed,
with measured tissue concentrations of D4, D5 and D6 compounds in fish
and benthic invertebrates compared with critical target lipid body
burdens (CTLBBs) as estimated with the target lipid model (TLM). Acute
and chronic toxicity data for these compounds were compared with data
for nonpolar organic chemicals to validate application of the TLM in
this effort. The analysis was extended to estimate the contribution from
metabolites to the overall tissue residues using a food chain model
calibrated to laboratory and field data. Concentrations of the compounds
in biota from several trophic levels, including fish, are well below the
estimated CTLBBs associated with acute and chronic effects. The data
support the use of the TLM model (which assumes a non-polar narcosis
mode of action) for D4, D5 and D6 and demonstrate their generally low
PFA, 2017, Siloxane Category Report for Environmental Endpoints,
Redman, A. D., Mihaich, E., Woodburn, K., Paquin, P., Powell, D.,
McGrath, J. A. & Di Toro, D. M. (2012). Tissue-Based Risk Assessment of
Cyclic Volatile Methyl Siloxanes. Environmental Toxicology and Chemistry
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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