Registration Dossier
Registration Dossier
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EC number: 201-177-9 | CAS number: 79-10-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: clinical case report
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermites de contact dans l'imprimerie, par procédé offset
- Author:
- Ducombs, MM. G. et al.
- Year:
- 1 974
- Bibliographic source:
- Soc. Francaise de dermatol. et de syphiligraphie, reunion de Nantes, seance du 27 avril 1974, 408-409
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- acute toxicity: dermal
- skin sensitisation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Unspecified epicutaneous tests and biopsies with workers showing contact dermatitis.
Test material
- Reference substance name:
- Acrylic acid
- EC Number:
- 201-177-9
- EC Name:
- Acrylic acid
- Cas Number:
- 79-10-7
- Molecular formula:
- C3H4O2
- IUPAC Name:
- prop-2-enoic acid
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 13
- Sex: male
- Age: 20-52 years
- Known diseases: dermatitis - Ethical approval:
- other: ethical appoval given for epicutaneous tests, but only in one case for biopsies
- Route of exposure:
- dermal
- Reason of exposure:
- unintentional, occupational
Results and discussion
Any other information on results incl. tables
The coworkers only showed effects when exposed to 4 printing inks. To determine the cause of dermatitis (sensitizing or corrosive potential of the inks) it was necessary to take biopsies, but the persons already tested did not want to participate at this procedure. There was only one other volunteer, who was examined by taking a biopsy. According to the authors it could be shown that the effects on the skin were the result of polymerisation of acrylic resins, a reaction where about 16% acrylic acid were released.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
