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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

The lowest results are a 72 hour EC50 of 2.2 mg/L and a 72 hour NOEC of 0.44 mg/L, both for p-xylene.

Key value for chemical safety assessment

EC50 for freshwater algae:
2.2 mg/L
EC10 or NOEC for freshwater algae:
0.44 mg/L

Additional information

Data are available on the ecotoxicity of each of the xylene isomers to algae. The studies by Galassi et al (1988) and TNO (2004) followed OECD 201, whilst Herman et al (1990) used a non-standard method. All studies included analytical confirmation of the exposure concentrations.

The EC50 results reported from these studies for the different isomers are very similar, with a range of 2.2 -4.9 mg/L. The most conservative result from the individual isomers was reported by TNO (2004) for p-xylene. This was the only study that also reported NOEC values. These values will be used in the risk assessment.

A TLM-EqP modeling framework was used to support values derived experimentally and are presented as supporting studies.

The estimated EL50 values from TLM QSAR were 4.831 - 6.129 mg/L, and the estimated NOELR values from TLM QSAR were 0.925 - 1.174 mg/L.