Registration Dossier
Registration Dossier
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EC number: 207-312-8 | CAS number: 461-58-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Pre-1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Cyanoguanidine
- EC Number:
- 207-312-8
- EC Name:
- Cyanoguanidine
- Cas Number:
- 461-58-5
- Molecular formula:
- C2H4N4
- IUPAC Name:
- 1-cyanoguanidine
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Cyanoguanidine (purity 99. 9 % ) from Sanwa Chemical Co., Ltd
Test animals
- Species:
- rat
- Strain:
- Fischer 344/DuCrj
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Five 9-week old female F344 / DuCrj rats (SPF Japan Charles River Co. ) were fasted for 4 hours before the administration of the test material.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was dispersed in distilled water and a 20 or 30 g / kg body weight dose was orally administered once.
- Doses:
- 20 and 30 g / kg body weight
- No. of animals per sex per dose:
- 5 female
- Control animals:
- no
- Details on study design:
- Five 9-week old female F344/DuCrl rats (SPF Japan Charles River Co. ) were fasted for 4 hours be- fore the administration of the specimen. The test sub- stance was dispersed in distilled water and a 20 or 30 g/kg body weight dose was orally administered once.
- Statistics:
- None.
Results and discussion
- Preliminary study:
- Not performed.
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 30 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 30 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Body temperature decrease, slowing of movement, cyanosis, lying two hours later, cyanosis, etc. were observed 1 hour after administration in the 30,000 mg/kg body weight administration group. However, 18 hours after administration these symptoms recovered
- Gross pathology:
- No abnormal findings were found at the time of necropsy performed one week after administration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- There were no mortalities and no symptoms which were not reversible after 18 hours (except diarrhea) at the high dose of 30,000 mg/kg bw.
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