Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-580-7 | CAS number: 64-19-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, near guideline animal experimental study, published in peer reviewed literature, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetic acid
- EC Number:
- 200-580-7
- EC Name:
- Acetic acid
- Cas Number:
- 64-19-7
- Molecular formula:
- C2H4O2
- IUPAC Name:
- acetic acid
- Details on test material:
- No details reported.
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- human
- Sex:
- female
Administration / exposure
- Type of coverage:
- other: in vitro (enclosed system)
- Vehicle:
- water
- Duration of exposure:
- Finite dose experiments: 8h
Infinite dose experiments: 48-51h - Doses:
- Finite dose experiments: 100mg/ml
Infinite dose experiments: 95.8, 21.0, 4.66, 0.82, 0.26mg/ml - No. of animals per group:
- 3-4
Results and discussion
- Absorption in different matrices:
- Membrane: 15±3.8%
Receptor cell: 27±15% - Total recovery:
- 95±2.2%
Percutaneous absorption
- Dose:
- 100mg/ml
- Parameter:
- percentage
- Absorption:
- 43 %
- Remarks on result:
- other: 8h
- Remarks:
- value in total of receptor cell and membrane, Kp=4±2.1 (10^-3cm/h)
Applicant's summary and conclusion
- Conclusions:
- The potential dermal absorption from a 100mg/ml aqueous solution of acetic acid is 43±18%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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