Registration Dossier
Registration Dossier
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EC number: 203-632-7 | CAS number: 108-95-2
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data migrated from IUCLID4 based on EU RAR 2006 and therefore assumed to be reliable
Data source
Reference
- Title:
- No information
- Author:
- Gaido, K. Wierda, D. (1985): Modulation of stroma cell function in DBA/2J and B6CeF1 mice exposed to benzene or phenol. Toxicol. Applied Pharmacol. 81, 469-475
Materials and methods
- Principles of method if other than guideline:
- Method: other
Test material
- Reference substance name:
- Phenol
- EC Number:
- 203-632-7
- EC Name:
- Phenol
- Cas Number:
- 108-95-2
- Molecular formula:
- C6H6O
- IUPAC Name:
- phenol
- Details on test material:
- TS-Freetext:
no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: two strains
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 4 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
200 mg/kg bw
- Control animals:
- no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext: Phenol applicated intraperitoneally in mice from two strains on 4 days at daily dosages of 200 mg/kg suppress bone marrow stromal cell function to support in vitro hemopoiesis of granulocyte/ monocyte precursors in cocultured bone marrow cells from untreated animals.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
