Registration Dossier
Registration Dossier
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EC number: 205-685-1 | CAS number: 147-14-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxic effects of copper phthalocyanine-based dyes.
- Author:
- Kurlandsky BA, Torshina NL and Balabanova EL
- Year:
- 1 993
- Bibliographic source:
- Current Toxicology 1 (3/4): 243-246
Materials and methods
- Principles of method if other than guideline:
- No data given.
- GLP compliance:
- no
Test material
- Reference substance name:
- 29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
- EC Number:
- 205-685-1
- EC Name:
- 29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
- Cas Number:
- 147-14-8
- Molecular formula:
- C32H16CuN8
- IUPAC Name:
- copper polyphthalocyanine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Pigment Blue 15
- Analytical purity: no data given
Test animals
- Species:
- rat
- Strain:
- other: albino rats
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: DMSO
- Doses:
- 3000 mg/kg bw
- No. of animals per sex per dose:
- No data given.
- Control animals:
- not specified
- Details on study design:
- No data given.
Results and discussion
- Mortality:
- No information was given regarding mortality of the animals.
- Clinical signs:
- The authors of the publication reported the following clinical signs:
- A reduction of diuresis (test -2.1 +- 0.19 ml, control -7.3 +- 0.6 ml) and an increasing of the protein content in urea (test 2.3 +- 0.19 mg/ml, control 1.86 +- 0.07 mg/ml) was seen.
- No test substance or the products of its metabolism were found in the blood.
- The increasing of Cu2+ content in the blood serum of the test animals (in test 1.80+-0.08 mg/ml, in control 1.60+-0.02 mg/ml) was connected with the content of up to 0.2% of the soluble copper salts in the pigment, and was reversible after removing the Cu2+ impurity.
Applicant's summary and conclusion
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