Registration Dossier
Registration Dossier
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EC number: 200-539-3 | CAS number: 62-53-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA guideline of 1982
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Aniline
- EC Number:
- 200-539-3
- EC Name:
- Aniline
- Cas Number:
- 62-53-3
- Molecular formula:
- C6H7N
- IUPAC Name:
- aniline
- Details on test material:
- - Name of test material (as cited in study report): aniline
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8 weeks
- Weight at study initiation: 230-250g
Administration / exposure
- Route of administration:
- other: inhalaton exposure to vapour/aerosol
- Type of inhalation exposure:
- head only
- Vehicle:
- other: humidified and oxygen-enriched houseline air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- every 30 min
- Duration of exposure:
- 4 h
- Concentrations:
- 681, 790, 834 and 896 ppm
- No. of animals per sex per dose:
- 10/dose group
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 839 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: 839 ppm = 3.27 mg/L, head-only exposure to vapour/aerosol
Any other information on results incl. tables
Deaths occurred at concentrations of 790 ppm (2/10 rats died), 834 ppm (5/10 rats died) and 896 ppm (8/10 rats died). Clinical signs at exposure included cyanosis, tremors and prostration up to 48 hours post-exposure, corneal clouding up to 14 days post-exposure, reddish brown nasal discharge and chromodachryorrhea. Clinical signs post exposure were pallor and rales, head and facial hair loss; after 4 hours exposure to 790 ppm mild to severe corneal damage was detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
