Registration Dossier
Registration Dossier
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EC number: 931-296-8 | CAS number: 97862-59-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
see "General Justification for Read-Across" attached to IUCLID section 13
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Mutual read across from the AAPBs to one another is justified:
a) Based on the information given in section 1, it can be concluded that all AAPBs mentioned above are similar in structure, since they are manufactured from similar resp. identical precursors under similar conditions and all contain the same functional groups. Thus a common mode of action can be assumed.
b) The content of minor constituents in all products are comparable and differ to an irrelevant amount.
c) The only deviation within this group of substances is a minor variety in their fatty acid moiety, which is not expected to have a relevant impact on intrinsic toxic or ecotoxic activity and environmental fate. Potential minor impact on specific endpoints will be discussed in the specific endpoint sections.
The read-across hypothesis is based on structural similarity of target and source substances. Based on the available experimental data, including key physico-chemical properties and data from toxicokinetic, acute toxicity, irritation, sensitisation, genotoxicity and repeated dose toxicity studies, the read-across strategy is supported by a quite similar toxicological profile of all five substances.
The respective data are summarised in the data matrix; robust study summaries are included in the Technical Dossier in the respective sections.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
see "General Justification for Read-Across" attached to IUCLID section 13
3. ANALOGUE APPROACH JUSTIFICATION
see "General Justification for Read-Across" attached to IUCLID section 13
4. DATA MATRIX
see "General Justification for Read-Across" attached to IUCLID section 13 - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- geometric mean of all available studies
- Effect conc.:
- 1.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Remarks:
- geometric mean of all available studies
- Effect conc.:
- 0.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth rate
- Conclusions:
- In a weight of evidence approach, considering all available information for the endpoint aquatic toxicity, the ecotox profile of C8-18 AAPB is characterised by an acute aquatic toxicity in the range of >1 to ≤ 10 mg/L. For practical reasons (to name a value for the algae effect concentration) the algae study with the lowest acute effect result within this range is used for the assessment of algae toxicity: 72h-ErC50 = 1.5 mg a.i./L, 72h-NOEC = 0.3 mg a.i./L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 07.12.1993-10.12.1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- without analytical monitoring
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A stock solution (200 mg/L) was prepared. The test concentrations were obtained by dilution
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): no vehicle used
- Evidence of undissolved material (e.g. precipitate, surface film, etc): not reported - Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name: Desmodesmus subspicatus CHODAT (current scientific name)
- Strain: SAG 86.81
- Source (laboratory, culture collection): own breeding (origin: Sammlung von Algenkulturen, Uni Göttingen)
- Age of inoculum (at test initiation): 4 d
- Method of cultivation: The algae were cultivated in sterile flasks with ca. 2 L culture medium according to Kuhl (1962) at room temperature (light intensity: 35-70 µE/m² x s; continuous lighting)
ACCLIMATION
- Acclimation period: 4 d
- Culturing media and conditions (same as test or not): no
- Any deformed or abnormal cells observed:not reported - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Test temperature:
- 23 +/- 2°C
- pH:
- 7.79-8.13 (start), 8.03-8.19 (end)
- Nominal and measured concentrations:
- 0.32; 1; 3.2; 10; 32; 100 mg product/l
corresponding to 0.098, 0.31, 0.98, 3.1, 9.8, 31 mg active substance/l - Details on test conditions:
- TEST SYSTEM
- Test vessel: plastic cuvettes ( cross section dimension=50 mm, clear, with cover, 20 ml nominal volume)
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: plastic/20 mL/10 mL/10 mL
- Aeration: not reported
- Type of flow-through (e.g. peristaltic or proportional diluter): test conducted under static conditions
- Initial cells density: 7 x 10³ cells/mL
- Control end cells density: 110 x 10³ cells/mL
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
- Culture medium different from test medium: yes
- Intervals of water quality measurement: pH was measured at the beginning and at the end of the test; temperature was continuously measured
OTHER TEST CONDITIONS
- Sterile test conditions: not reported
- Adjustment of pH: no
- Photoperiod: continuous light
- Light intensity and quality: 35-70 µE/m² x sec (acc. to OECD: 120 µE/m² x sec)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : biomass, growth rate
- Chlorophyll measurement: Algal cells density was determined by measuring chlorophyll a-fluorescence via chlorophyll-fluorometrie. Chlorophyll fluorescence was determined at 0; 24; 48 and 72h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: ca. 3
- Range finding study: not reported - Reference substance (positive control):
- not specified
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 14.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 9.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- biomass
- Details on results:
- RESULTS: EXPOSED
- Nominal/measured concentrations: nominal
EC0 was obtained from concentration-response relation and not calculated;
EC10 and EC50 were determined according to DIN 38412 L9 (graphically from a log concentration/biomass or growth rate inhibition plot)
Results, based on nominal concentration:
ErC0 : 3.2 mg product/l
ErC10 : 7.0 mg product/l
ErC50 : 48 mg product/l
Results for the endpoint biomass inhibition after 72 h:
EbC0 : 3.2 mg product/l
EbC10 : 4.9 mg product/l
EbC50 : 30 mg product/l
Assuming a content of 30.7% active substance:
Results for the endpoint growth rate inhibition after 72 h:
ErC0 : 0.98 mg active substance/l
ErC10 : 2.1 mg active substance/l
ErC50 : 14.7 mg active substance/l
Results for the endpoint biomass inhibition after 72 h:
EbC0 : 0.98 mg active substance/l
EbC10 : 1.5 mg active substance/l
EbC50 : 9.2 mg active substance/l - Reported statistics and error estimates:
- SigmaPlot, Jandel Scientific Version 5.0 (1992)
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a 72 hour toxicity study conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test), the cultures of Desmodesmus subspicatus were exposed to C8-18 AAPB under static conditions. The 72 h ErC50 and 72 h EbC50 were 14.7 and 9.2 mg active substance/l nominal, respectively.
- Executive summary:
In a 72 hour toxicity study conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test), the cultures of Desmodesmus subspicatus were exposed to C8 -18 AAPB at nominal concentrations of 0, 0.098, 0.31, 0.98, 3.1, 9.8, and 31 mg active substance/L under static conditions. The 72 h ErC50 and 72 h EbC50 were 14.7 and 9.2 mg active substance/L nominal, respectively. There were no compound related phytotoxic effects.
This study is regarded as reliable with restrictions and satisfies the guideline requirements for a toxicity study with freshwater algae.
Results Synopsis
Test Organism: Desmodesmus subspicatus
Test Type: Static
Growth rate:
72 hr ErC50: 14.7 mg a.i./L
Biomass:
72 hr EbC50: 9.2 mg a.i./L(all values refer to nominal concentations)
Endpoint(s) Effected: growth rate, biomass
Referenceopen allclose all
Number of cells/ml:
Test item | 0h | 24h | 48h | 72h |
[mg/l] | | | | |
--------------------------------------------
| number of cell [*10E3]
control | 7 | 13 | 45 | 110 |
0.32 | 8 | 14 | 39 | 103 |
1.0 | 8 | 16 | 43 | 107 |
3.2 | 7 | 10 | 43 | 123 |
10.0 | 8 | 13 | 32 | 93 |
32.0 | 7 | 9 | 24 | 64 |
100 | 9 | 4 | 4 | 5 |
Inhibition of growth rate and biomass integral after 72h:
Test item | growth | inhibition | inhibition |
[mg/l] | grate | biomass | growth rate|
| | [%] | [%] |
---------------------------------------------------
control | 0.94 | --- | --- |
0.32 | 0.86 | 12.3 | 9.2 |
1.0 | 0.87 | 4.2 | 8.0 |
3.2 | 0.94 | 0.8 | 0.7 |
10.0 | 0.81 | 26.7 | 14.1 |
32.0 | 0.72 | 51.7 | 23.8 |
100 | 0.00 | 100.0 | 100.0 |
Description of key information
The toxicity of C8-18 AAPB, Coco AAPB and C12 AAPB to fresh water and salt water algae was investigated in 8 valid studies. In a weight of evidence approach, considering all available information for the endpoint aquatic toxicity, the ecotox profile of C8-18 AAPB is characterised by an acute aquatic toxicity in the range of >1 to ≤ 10 mg/L. For practical reasons (to name a value for the algae effect concentration) the algae study with the lowest acute effect result within this range is used for the assessment of algae toxicity: 72h-ErC50 = 1.5 mg a.i./L, 72h-NOEC = 0.3 mg a.i./L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1.5 mg/L
- EC10 or NOEC for freshwater algae:
- 0.3 mg/L
Additional information
One algal toxicity study conducted with C8-18 AAPB is available as well as further studies conducted with the closely related source substances C12 AAPB, C8-18 and C18 unsatd. AAPB (Coco AAPB). A justification for read-across is given below.
The toxicity of C8-18 AAPB, Coco AAPB and C12 AAPB to fresh water and salt water algae was investigated in 8 valid studies,7 fresh water algae studies with Desmodesmus subspicatus and Pseudokirchnerella subcapitata (72h-ErC50 1.5 - > 334 mg/L a.i.) and one marine algae study with Skeletonema costatum (72 -h- ErC50 0.97 mg/L a.i.).
In a weight of evidence approach, considering all available information for the endpoint aquatic toxicity, the ecotox profile of C8-18 AAPB is characterised by an acute aquatic toxicity in the range of >1 to ≤ 10 mg/L. For practical reasons (to name a value for the algae effect concentration) the algae study with the lowest acute effect result within this range is used for the assessment of algae toxicity: 72h-ErC50 = 1.5 mg a.i./L, 72h-NOEC = 0.3 mg a.i./L.
Data included in the weight of evidence approach
1. In a test conducted according to DIN 38412, part 9 (comparable to OECD Guideline 201), the cultures of Desmodesmus subspicatus were exposed to Coco AAPB at nominal concentrations of 0.003, 0.009, 0.03, 0.09, 0.3, 0.9, 3.0 mg a.i./L under static conditions for 72 h. Originally, the data were evaluated according to the test guideline (DIN 38412, Part 9) using the EDV-program of Mr. Holtmann (Henkel KGaA). Based on today knowledge, this calculation model is no longer valid or only valid with restriction. Therefore, a recalculation of the 72 h EC50 values was performed taking into account the OECD principles. The 72 h ErC50, EbC50, and NOEC were found to be 1.5, 0.57, and 0.3 mg a.i./L nominal, respectively.
2. In a 72 hour toxicity study conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test) and EU Method C.3 (Algal Inhibition test), the cultures of Desmodesmus subspicatus were exposed to Coco AAPB (30.9 % active matter) at nominal concentrations of 0.97, 1.93, 3.86, 7.72, 15.45, 30.9 mg active substance/L under static conditions. The 72 h NOEC, LOEC and EC50 values based on growth rate were 3.86, 7.73 and 9.86 mg a.i./L nominal, respectively. The 72 h NOEC, LOEC and EC50 values based on biomass were 1.93, 3.86 and 5.31 mg a.i./L nominal, respectively. There were no compound related phytotoxic effects. This toxicity study is regarded as reliable without restriction and satisfies the requirements of the guideline.
3. In a 72 hour acute toxicity study, the cultures of Desmodesmus subspicatus were exposed to C12 AAPB at nominal concentrations of 0.03, 0.096, 0.3, 0.96, 3, 9.6 mg a.i./L / under static conditions in accordance with the OECD Guideline 201 (2006). The 72 h ErC50 value based on inhibition of specific growth rate was 3.15 mg a.i./L, the 72 h EyC50 value based on yield inhibition was 1.01 mg a.i./L, respectively. The 72 h NOEC based on growth rate and yield was determined to be 0.3 mg a.i./L nominal. No abnormalities were noted. The test item effects were observed to be reversible at the test concentrations 0.32 - 32 mg test mat. /L. (0.096 - 9.6 mg a.i./L). This toxicity study is classified as reliable without restriction and satisfies the requirements of the OECD Guideline 201 Alga, Growth inhibition test (2006).
4. In a 72 hour toxicity study conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test), the cultures of Desmodesmus subspicatus were exposed to C8 -18 AAPB at nominal concentrations of 0, 0.098, 0.31, 0.98, 3.1, 9.8, and 31 mg active substance/L under static conditions. The 72 h ErC50 and 72 h EbC50 were 14.7 and 9.2 mg active substance/L nominal, respectively. There were no compound related phytotoxic effects. This study is regarded as reliable with restrictions and satisfies the guideline requirements for a toxicity study with freshwater algae.
5. The toxicity of Coco AAPB to Scenedesmus subspicatus was investigated in a study conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test), EU Method C.3 (Algal Inhibition test) and ISO 8692 (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum). Scenedesmus subspicatus was exposed to nominal concentrations of 0 (control), 1.0, 1.8, 3.2, 5.6, and 10.0 mg a.i./L for 72 h under static conditions. The 72 h EC50 and NOEC based on biomass and growth rate were determined to be 5.6 (growth rate) and 4.66 (biomass) and 1.8 mg a.i./L nominal (growth rate and biomass), respectively. This study is regarded as reliable with restrictions.
6. The toxicity of Coco AAPB to Selenastrum capricornutum was investigated in a study conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test), EU Method C.3 (Algal Inhibition test) and ISO 8692 (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum). Selenastrum capricornutum was exposed to nominal concentrations of 0 (control), 0.56, 1.0, 1.8, 3.2, 5.6, and 10.0 mg a.i./L for 96 h under static conditions. The 96 h ErC50, EbC50 and NOEC were determined to be >10 (growth rate) and ca. 8 (biomass) and 3.2 mg a.i./L nominal (growth rate and biomass), respectively. This study is regarded as reliable with restrictions.
7. In a test conducted according to OECD Guideline 201, the cultures of Desmodesmus subspicatus were exposed to Coco AAPB at nominal concentrations of 0 (control), 4, 10, 25, 63, 158, and 395 mg dry residue/L for 72 h under static conditions. The stability of the test item was measured via TOC measurements. The recovery rate was >80%. After 72 h, the measured values differed from freshly prepared solutions by < 20%. The 72 h EC50 were determined to be 37.2 (biomass) and >334 mg a.i./L nominal (growth rate), respectively. This study is regarded as reliable with restrictions.
8. The toxicity of Coco AAPB to the marine phytoplankton Skeletonema costatum was investigated in a study conducted according to ISO 10253 (Water quality - Marine Algal Growth Inhibition Test with Skeletonema costatum and Phaeodactylum tricornutum). Cultures of Skeletonema costatum in the exponential growth phase were exposed to nominal concentrations of 0.32, 1.0, 3.2, 5.6, and 10 mg product/L corresponding to 0.01, 0.36, 1, 2, and 3.6 mg a.i./L under static conditions for 72 h. The 72 h ErC50 and NOEC values were determined to be 2.05 mg product/L and 1 mg product/L (nominal each), respectively.
Effect concentrations based on a.i. as named in study report CoA (certificate of analysis) (= solids - sodium chloride) and recalculated for a.i. of registration substance composition (IUCLID chapter 1.2): 72 h ErC50: 0.97 mg a.i./L, 72 h NOEC: 0.47 mg a.i./L.
Effect concentrations based on a.i. as named in study report CoA (certificate of analysis) (= solids - sodium chloride): 72 h ErC50: 0.74 mg a.i./L, 72 h NOEC: 0.36 mg a.i./L.
This toxicity study is regarded as reliable without restriction.
Justification for read-across
For details on substance identity and detailed (eco)toxicological profiles, please refer also to the general justification for read-across given at the beginning of the CSR and attached as pdf document to IUCLID section 13.
This read-across approach is justified based on structural similarities. All AAPBs contain the same functional groups. Thus a common mode of action can be assumed.
The only deviation within this group of substances is a minor variety in their fatty acid moiety (chain length and degree of unsaturation), which is not expected to have a relevant impact on intrinsic ecotoxicological properties.
a. Structural similarity and functional groups
Alkylamidopropyl betaines (AAPBs) are – with the exception of C12 AAPB - UVCB substances (Substances of Unknown or Variable composition, Complex reaction products or Biological materials), which are defined as reaction products of natural fatty acids or oils with dimethylaminopropylamine and further reaction with sodium monochloroacetate. AAPBs are amphoteric surfactants, which are characterized by both acidic and alkaline properties.
Their general structure is:
R-C(O)-NH-(CH2)3-(N(CH3)2)+-CH2-C(O)O-
R = fatty acid moiety
The fatty acids have a mixed, slightly varying composition with an even numbered chain length from C8 to C18. Unsaturated C18 may be included. Consequently, the AAPBs differ by their carbon chain length distribution and the degree of unsaturation in the fatty acid moiety. However, Lauramidopropyl betaine (C12 fatty acid derivate) is the major ingredient of all AAPBs covered by this justification as listed in table 1 “Substance identities” of the general justification for read-across.
The substances under evaluation share structural similarities with common functional groups (quaternary amines, amide bonds and carboxymethyl groups), and fatty acid chains with differences in chain length and degree of saturation.
b. Differences
Differences in acute ecotoxicity of the AAPBs could potentially arise from the following facts:
-Different amounts of different carbon chain lengths (carbon chain length distribution):
Higher amounts of higher chain lengths and corresponding lower amounts of lower chain length could result in a rising average lipophilicity. However, the main component for all AAPBs is C12 AAPB. Relevant effects on ecotoxicity are not to be expected.
- Different amounts of unsaturated fatty ester moieties:
Effects may be expected for e.g. physical state, but are not considered to be of relevance for ecotoxicity.
Comparison of toxicity to aquatic algae and cyanobacteria
Endpoint |
Source substances |
Target substance |
|
|
C12 AAPB |
C8-18 and C18 unsatd. AAPB |
C8-18 AAPB |
Toxicity to aquatic algae and cyanobacteria |
WoE.Toxicity to aquatic algae and cyanobacteria: 4292-10-8_9.1.2_Betaines consortium_2007_OECD 201
OECD Guideline 201 (Alga, Growth Inhibition Test),Desmodesmus subspicatus, freshwater, static
Reliability: 1 (reliable without restriction), GLP |
WoE.Toxicity to aquatic algae and cyanobacteria: 61789-40-0_9.1.2_Henkel_1992_DIN 38412 part 9
Weight of evidence
Reliability: 2 (reliable with restrictions), GLP |
WoE.Toxicity to aquatic algae and cyanobacteria: 97862-59-4_9.1.2_THG_1993e_OECD 201 Weight of evidence
Reliability: 2 (reliable with restrictions), GLP |
WoE.Toxicity to aquatic algae and cyanobacteria: 61789-40-0_9.1.2_CEFIC_CESIO_2006b_OECD 201
OECD Guideline 201 (Alga, Growth Inhibition Test),Desmodesmus subspicatus, freshwater, static
Reliability: 1 (reliable without restriction), GLP |
|||
WoE.Toxicity to aquatic algae and cyanobacteria.61789-40-0_9.1.2_Acute-algae_Unilever_A19_AL-L17-01 Weight of evidence
Reliability: 2 (reliable with restrictions), no GLP
|
|||
WoE.Toxicity to aquatic algae and cyanobacteria.61789-40-0_9.1.2_Acute-algae_Unilever_A18_AL-L474-01
Weight of evidence
96 h EC50 = ca. 8 mg/Lact. ingr. (nominal) based on: biomass
Reliability: 2 (reliable with restrictions), no GLP
|
|||
WoE.Toxicity to aquatic algae and cyanobacteria: 61789-40-0_9.1.2_Hüls_1996_EEC 92-69 C3
Reliability: 2 (reliable with restrictions), GLP |
|||
WoE.Toxicity to aquatic algae and cyanobacteria.61789-40-0_9.1.2_Marine_72h_Skeletonema costatum_Rhodia_Mirataine-BET-C37_ISO_2008
Reliability: 1 (reliable without restriction), GLP |
|||
72 h ErC50 values were in the range of 0.74 to >334 mg/L; 72 h NOEC (or EC10) values were in the range of 0.3 to 37.2 mg/L.
In a weight of evidence approach, considering all available information for the endpoint aquatic toxicity, the ecotoxicity profile of the AAPBs is characterised by an acute aquatic toxicity in the range of >1 to ≤ 10 mg/L. For practical reasons (to name a value for the algae effect concentration) the algae study with the lowest acute effect result within this range is used for the assessment of algae toxicity: 72h-ErC50 = 1.5 mg a.i./L, 72h-NOEC = 0.3 mg a.i./L.
Quality of the experimental data of the analogues:
The available data are adequate and sufficiently reliable to justify the read-across approach.
The available studies were conducted according to OECD Guideline 201 or EU method C.4 (marine algae: ISO 10253) and were reliable (RL1) or reliable with restrictions (RL2).
The test materials used in the respective studies represent the source substance as described in the hypothesis in terms of substance identity and minor constituents.
Overall, the study results are adequate for the purpose of classification and labelling and risk assessment.
Conclusion
Based on structural similarities of the target and source substancesas presented above and in more detail in the general justification for read across, it can be concluded that the available data from the source substances C12 AAPB and C8-18 and C18 unsatd. AAPB are also valid for the target substance C8-18 AAPB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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