Registration Dossier
Registration Dossier
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EC number: 205-582-1 | CAS number: 143-07-7
Endpoint summary
Administrative data
Description of key information
Additional information
Studies on the acute aquatic toxicity of lauric acid (CAS 143-07-7) are available for all three trophic levels (fish, invertebrates and algae), resulting in LC50(96h) of 5.0 mg/L for fish and and EC50(48h) of 3.6 mg/L for daphnia, respectively. The toxicity study on algae showed no effects up to the limit of water solubility.
Chronic fish toxicity data with lauric acid are not available. Therefore chronic fish toxicity data from a surrogate substance, sodium laurate (CAS 629-25-4, C12) are taken into account. From this test it can be concluded, that long-term effects on fish up to the limit of water solubility are also not to be expected for lauric acid.
One long term toxicity study on invertebrates with lauric acid is available (NITE 2001). Since severe deficiencies such as an invalid solvent control, instable test substance concentration, no defined dose-response curve and unknown fate of the test substance had been stated, the study was therefore disregarded. The chronic toxicity on daphnia was assessed based on a study for decanoic acid (CAS 334-48-5) that was conducted recently within an ongoing test programme in cooperation with Fraunhofer Institute IME (FhG) in Schmallenberg/Germany in 2012. In the test no immobilisation occurred throughout the test, neither the mean cumulative offspring was affected by the test substance. NOELR of >= 1.3 mg/L (measured, TWA) was determined that is corresponding to the nominal loading of 5 mg/L. An additional study on chronic invertebrate toxicity with lauric acid is underway in order to overcome methodological deficiencies due to rapid decay of the test substance and to verify the hazard assessment.
The toxicity to microorganisms is covered by read across data from octanoic acid (CAS 124-07-2) which showed no toxic effect (EC10 (18 h) = 912 mg/L). In the light of this study no toxic effects on microorganisms (Pseudomonas putida) can be deduced for lauric acid.
A detailed justification for the grouping of chemicals and read-across is provided in the Chemical Safety Report (CSR, see section 13 of the technical dossier).
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